The development of pharmacometric models is a complex, multi-step process. Generally, it begins with an informed starting model, which is…
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Pharmpy: a versatile open-source library for pharmacometrics
The development of pharmacometric nonlinear mixed effect models is a complex, multi-step process. Generally, it begins with an informed starting…
Read moreRDarwin: An R package for Machine Learning using pyDarwin and Certara’s pharmacometrics modeling language (PML) and NLME engine
Introduction/Objectives: RDarwin (1) is an R package that provides a set of R functions to enable setup and execution of pyDarwin…
Read morepedPower – An R package to aid pediatric clinical trial design and exposure evaluation
Introduction As one step in the pediatric development of drugs that have been evaluated in adults, pediatric trials are conducted…
Read morePIPETapps: a Compilation of R Shiny Apps for Clinical Pharmacology and Pharmacometrics using Cloud Computing Tools
Objectives: Modeling and simulation tools for pharmacokinetics (PK) and pharmacodynamics (PD) analysis usually require advanced abilities and knowledge of users…
Read moreDeveloping a shiny app to expedite the simulation of PKPD profiles of mAbS and exploration study designs
Objectives: Monoclonal antibodies (mAbs) are an essential and expanding class of therapeutic agents [1]. MAbs possess a high degree of…
Read moreData Repository to Enable Organization and Collaboration for Pharmacometric Analysis
Objectives: Successful implementation of model-informed drug development requires the interdisciplinary teams to collaborate efficiently and effectively. The management and organization of…
Read moreTucuxi: Open source MIPD software
Monitoring of circulating drug concentrations in the patients, also called “therapeutic drug monitoring” (TDM), represents the best way to optimize…
Read morePsN and Xpose
PsN is a toolbox for population PK/PD model building using NONMEM. It has broad functionality ranging from results extraction from…
Read moreBAST: Clinical Trial Simulator and Service Supermarket
BAST Clinical Trial Simulator The BAST CTS runs on an R/Shiny interface. It is applied to decisions regarding: Optimal clinical…
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