Introduction: The introduction of the finite absorption time (F.A.T.) concept [1,2] was followed by the development of the pertinent PBFTPK…
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IQReport: A Software Solution for Enhanced Report Generation Ensuring Workflow Efficiency, Traceability, and Reproducibility
Introduction/Objectives: Introducing the software solution IQReport, a software developed by IntiQuan, which aims to improve pharmacometric reporting. It enables the…
Read moreSAAM II: Selected Software Use Cases in Modern PK-PD Data Analysis
Introduction: Simulation Analysis and Modeling II (SAAM II) is perhaps the most renowned software for compartmental modeling. Compartmental modeling is the…
Read moreConstructing the ERAMET Digital Research Environment (DRE)
Objectives: ERAMET (Ecosystem for RApid adoption of modelling and simulation METhods) is a recently funded (HORIZON-HLTH-2023-IND-06-04) initiative to address regulatory…
Read moreFinch Studio: A Next Generation NONMEM Modeling Workbench
Introduction: Finch Studio is an integrated modeling environment for pharmacometricians, clinical pharmacologists, and other team members to visualize, develop, and…
Read moreHetaProject – a Single Open Source Platform for Modeling, Simulation and Parameters Estimation in QSP
Objectives: Pharmacological modeling is evolving towards large-scale dynamical models [1]. A typical QSP project may include thousands of molecular components…
Read moreParameters Estimation, Identifiability and Predictability Analysis in Systems Biology with HetaSimulator and LikelihoodProfiler
Introduction: Systems Biology and QSP Modeling workflow consists of time consuming and computationally demanding procedures, which include developing a model…
Read moreSecure and Scalable Computational Environment for Virtual Patients Simulations
Introduction: One of the main computational challenges of QSP modeling is the possibility to perform thousands of simulations with large-scale…
Read moreCYTOCON DB as storage of unified data on in vivo human concentrations of cells and molecules in health and disease
Objectives: Quantitative Systems Pharmacology (QSP) models require their validation via comparison of model simulations with in vivo baseline data measured in…
Read morePharmpy: a versatile open-source library for pharmacometrics
The development of pharmacometric nonlinear mixed effect models is a complex, multi-step process. Generally, it begins with an informed starting…
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