Thursday 16 October, 2025
Objectives: Traditional approaches to measurement scales generally disregard the underlying nature of the subcomponent data. In contrast, item response theory…
Read morePoster: Other Drug/Disease Modelling
A Target-Mediated Drug Disposition model to quantify the relationship between Anti-CD3 monoclonal antibody and CD3/TCR receptors in Patients with autoimmune diseases.
Thursday 16 October, 2025
Objectives: Otelixizumab is a monoclonal antibody (mAb) directed against human CD3ε, which forms part of the CD3/T-cell receptor (TCR) complex…
Read moreA Target-Mediated Drug Disposition model integrated with a T lymphocyte pharmacodynamic model for Otelixizumab.
Thursday 16 October, 2025
Objectives: Otelixizumab is a monoclonal antibody currently being investigated in autoimmunity. It is directed against human CD3ε on T lymphocytes….
Read moreExperimental design based on mechanistic mathematical modeling of body composition and energy turnover
Thursday 16 October, 2025
Objectives: Experimental studies of drugs related to appetite, metabolism, and energy expenditure often require rigorous monitoring of food intake and…
Read moreDevelopment of a Disease Progression Model in Korean Patients with Type 2 Diabetes Mellitus(T2DM)
Thursday 16 October, 2025
Objectives: T2DM is a progressive disease. Decreasing β-cell function, increasing insulin resistance and increasing fasting plasma glucose levels are the…
Read moreQuantitative Analysis of Reflux Episodes in Gastroesophageal Reflux Disease (GERD)
Thursday 16 October, 2025
Background: The prevalence of gastroesophageal reflux disease (GERD) is about 30% in Western populations and 10% in Asian populations and…
Read moreBayesian dose individualisation provides good control of warfarin dosing.
Thursday 16 October, 2025
Objectives: Warfarin is a difficult drug to dose accurately and safely due to large inter-individual variability in dose requirements. Current…
Read morePopulation PK Modeling of Dapivirine Released from Vaginal Rings
Thursday 16 October, 2025
Objectives: Dapivirine is a non-nucleoside reverse transcriptase inhibitor with potent antiviral activity against HIV-1. International Partnership for Microbicides has developed…
Read moreSignificant changes in pharmacokinetics of sufentanil during target controlled infusion of sufentanil for cardiac anaesthesia.
Thursday 16 October, 2025
Objectives: Target controlled infusion (TCI) with sufentanil is usually performed with Gepts model [1], which was derived from patients undergoing…
Read morePharmacokinetics of free hydromorphone concentrations in patients after cardiac surgery
Thursday 16 October, 2025
Objectives: Hydromorphone (HM) is an opioid analgesic used to relieve moderate-to-severe pain. The pharmacokinetic models published so far [1] consider…
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