Thursday 16 October, 2025
Objectives: Gaucher disease (GD) [1] is a rare recessively inherited disorder due to the deficiency of lysosomal enzyme glucocerebrosidase. Several…
Read morePoster: Other Drug/Disease Modelling
Pharmacokinetics of Canakinumab and pharmacodynamics of IL-1β binding in cryopyrin associated periodic fever, a step towards personalized medicine
Thursday 16 October, 2025
Objectives: Canakinumab is a high-affinity fully human monoclonal antibody of the IgG1/k isotype, designed to bind and functionally neutralize the…
Read moreDesign optimization for characterization of rifampicin pharmacokinetics in mouse
Thursday 16 October, 2025
Objectives: To develop a population pharmacokinetic (POPPK) model for rifampicin in mice and to optimize pharmacokinetic sampling schedule for rifampicin…
Read morePK/PD assessment of tacrolimus nephrotoxicity in liver transplantation
Thursday 16 October, 2025
Objectives: The immunosuppresive drug tacrolimus (TAC) is key to prevent organ rejection in patients post liver transplantation. However, a severe…
Read morePopulation pharmacokinetic/pharmacodynamic modeling for transformed binary effect data of triflusal in healthy Korean male volunteers
Thursday 16 October, 2025
Objectives: Triflusal (2-acetoxy-4-trifluoromethyl benzoic acid; CAS 322-79-2) is a platelet antiaggregant with structural similarities to salicyclates, but which is not…
Read moreComparator based dose-response model prediction of clinical irrelevance following near miss bioequivalence results for Cmax
Thursday 16 October, 2025
Objectives: The two intermediate doses of a fixed dose combination in development had low Cmax exposures that did not meet…
Read moreQuantitative assessment of drug response in male patients with severe nocturia receiving a combined medication of solifenacin and tamsulosin
Thursday 16 October, 2025
Background: Nocturia, defined currently by the ICS as the complaint that an individual has to wake at night one or…
Read moreInter-patient variability of local vs. systemic effects of TNF-α-neutralizing antibodies in rheumatoid arthritis
Thursday 16 October, 2025
Objectives: To estimate the inter-patient variability in the rheumatoid arthritis (RA) disease state and in the pharmacokinetics and pharmacodynamics of…
Read moreNonlinear mixed effects evaluation of Hamilton Depression Rating Score following combination treatment of presynaptic- and postsynaptic glutamate receptor inhibitors in bipolar depression patients
Thursday 16 October, 2025
Objectives: Presynaptic- and postsynaptic glutamatergic modulation is associated with anti-depressant activity that takes several weeks to reach a maximal full…
Read morePopulation pharmacokinetics of tacrolimus to aid individualized dosing in kidney transplant recipients
Thursday 16 October, 2025
Objectives: Tacrolimus is a potent immunosuppressive agent, frequently used after kidney transplantation. High variability between subjects and dosing occasions in addition…
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