Thursday 16 October, 2025
Objectives: Dovitinib is a potent oral inhibitor of Receptor Tyrosine Kinases (FGFR, VEGFR, PDGFR). It is expected to be effective…
Read morePoster: Other Drug/Disease Modelling
Population Pharmacokinetic/Pharmacodynamic Modeling of Two Novel Neutral Endopeptidase Inhibitors in Healthy Subjects
Thursday 16 October, 2025
Objectives: UK-447,841 and UK-505,749 are two selective NEP inhibitors that are being investigated for the ‘as required' treatment of the…
Read moreTarget-mediated clearance of ofatumumab: a tale of different disease states
Thursday 16 October, 2025
Objectives: Ofatumumab is a CD20-targeted monoclonal antibody indicated for the treatment of patients with refractory chronic lymphocytic leukemia (CLL) and…
Read morePopulation pharmacokinetic analysis of robenacoxib in dogs with chronic osteoarthritis
Thursday 16 October, 2025
Objectives: A previous population analysis showed the preferential distribution of the coxib NSAID robenacoxib to inflamed joints in dogs [1]….
Read moreA joint PK/PD-PD model of levodopa in patients with Parkinson’s disease: Motor effect and Movement disorder
Thursday 16 October, 2025
Objectives: After several years of treatment with levodopa, patients with Parkinson’s disease often present movement disorders such as dyskinesia. This…
Read moreMathematical Model of Homeostasis of Endogenous Hormones Following Hormone Replacement Therapy
Thursday 16 October, 2025
Objectives: Hormone replacement therapy (HRT) is widely used to antagonize low levels of endogenous hormones as e.g. in menopause, hypogonadism,…
Read moreMechanism of Action of Jellyfish (Carukia barnesi) Envenomation and its Cardiovascular Effects Resulting in Irukandji Syndrome
Thursday 16 October, 2025
Objectives: Jellyfish stings in northern Australia cause significant morbidity and mortality [1]. One of the most popular jellyfishes, Carukia barnesi…
Read morePhysiologically-based PK/PD modeling for a dynamic cardiovascular system: structure and applications
Thursday 16 October, 2025
Objectives: A physiologically-based (PB) cardiovascular (CV) model including a representation of heart (left, right atrium and ventricle), pulmonary, organ and…
Read morePredicting the antihypertensive effect of Candesartan-Nifedipine combinations based on public benchmarking data.
Thursday 16 October, 2025
Objectives: Calcium channel blocker (CCB) and Angiotensin II receptor blocker (ARB) have demonstrated their efficacy in reducing blood pressure in…
Read moreModelling of Anti-Drug Antibodies Directed Against a Monoclonal Antibody
Thursday 16 October, 2025
Objectives: Monoclonal antibodies (mAbs) are an important class of biopharmaceuticals. Due to their nature as foreign proteins, they can induce…
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