Thursday 16 October, 2025
Objectives: To date, several pharmacokinetic (PK) models have been proposed for tacrolimus (TAC) in pediatric and adult patients after liver and…
Read morePoster: Other Drug/Disease Modelling
A linear mixed effect model describing the expression of peroxisomal ABCD transporters in CD34+ stem cell-derived immune cells of X-linked Adrenoleukodystrophy and control populations
Thursday 16 October, 2025
Objectives: X-linked Adrenoleukodystrophy (X-ALD) is a fatal neurodegenerative disorder with inflammatory demyelination of the brain caused by mutations in the…
Read moreA population approach to investigating hepatic intrinsic clearance in old age: Pharmacokinetics of paracetamol and its metabolites
Thursday 16 October, 2025
Objectives: The aims of this study were to investigate the pharmacokinetics of paracetamol and its sulfide and glucuronide metabolites in…
Read moreClinical relevance of albumin concentration in patients with Crohn’s disease treated with infliximab for recommendations on dosing regimen adjustments
Thursday 16 October, 2025
Objectives: A high proportion of patients affected by Crohn’s disease (CD) lose response to infliximab (IFX) in the long-term. Patients…
Read moreRefining the mechanism of CETP mediated lipid transfer in a stochastic model of lipoprotein metabolism and kinetics (LMK model)
Thursday 16 October, 2025
Objectives: The Cholesterol Ester Transfer Protein (CETP) mediates the transfer of cholesteryl esters (CE) and triglycerides (TG) between lipoprotein particles…
Read moreA mechanism-based population model for estimation of system parameters, vehicle effects and drug-induced body weight changes in diet induced obesity mice
Thursday 16 October, 2025
Objectives: To present a mechanism-based turnover model of body weight change in diet induced obesity (DIO) mice. The model discriminates…
Read moreLiterature databases: integrating information on diseases and their treatments.
Thursday 16 October, 2025
Objectives: Quantitative knowledge about the clinical efficacy of approved drugs makes it possible to interpret the efficacy of a candidate…
Read morePopulation Pharmacokinetics of Etanercept in Healthy Korean Male Volunteers
Thursday 16 October, 2025
Objectives: Etanercept is a soluble recombinant human tumor necrosis factor receptor (TNFR) fusion protein which is used for the treatment…
Read morePopulation pharmacokinetics of prothionamide in Korean tuberculosis patients
Thursday 16 October, 2025
Objectives: Prothionamide (PTH) is a thioamide drug that has been used for multidrug-resistant tuberculosis (MDR-TB). It is bactericidal and is…
Read moreModelling early viral hepatitis C kinetics in compensated cirrhotic treatment-experienced patients treated with triple therapy including telaprevir or boceprevir
Thursday 16 October, 2025
Objectives: ANRS MODCUPIC is a clinical study designed to provide a precise description of the early hepatitis C viral kinetics…
Read more