Thursday 16 October, 2025
Introduction: Several NONMEM [1] tools have been developed in recent years in R to support PK and PKPD analyses [2],…
Read morePoster: Methodology - Other topics
Comparison of Pumas and NONMEM in parameter estimation of a complex pharmacodynamic model
Thursday 16 October, 2025
Introduction: Pharmaceutical modeling and simulation (Pumas) software is a pharmacometrics software program developed on Julia language platform (1). Modeling and…
Read morePerformance evaluation of the full Automatic Model Development (AMD) tool when the true model is known
Thursday 16 October, 2025
Introduction: The Automatic Model Development (AMD) tool in Pharmpy is an open source tool for automatic population pharmacokinetic (PK) model…
Read moreAutomatized reporting in the applications of MonolixSuite
Thursday 16 October, 2025
Objectives: Monolix, a tool for parameter estimation in non-linear mixed effects models and model diagnosis, provides an efficient way to…
Read moreDevelopment of a level A in vitro/in vivo correlation (IVIVC) using applications of the MonolixSuite
Thursday 16 October, 2025
Objectives: Post-approval changes in manufacturing processes or approvals of new strengths of a drug product require expensive and often long…
Read moreCombining aggregate data and individual patient/subject data in model-based meta-analysis: An illustrative case study of tofacitinib in rheumatoid arthritis patients
Thursday 16 October, 2025
Objectives: A conventional model-based meta-analysis (MBMA) integrates aggregate data (AD) from multiple studies and may provide more power to detect…
Read moreLeveraging the Finite Absorption Time (F.A.T.) Concept for Advancing PBPK Modeling and Pharmacometric structural models: Moving MIDD to Model Informed Drug Development and Assessment (MIDDA)
Thursday 16 October, 2025
Introduction: The introduction of the finite absorption time (F.A.T.) concept [1,2] was followed by the development of the pertinent PBFTPK…
Read morePopulation pharmacokinetics of continuous infusion ampicillin in the treatment of enterococcal infections in adult hospitalised patients
Thursday 16 October, 2025
Acknowledgement: This project has received funding from European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant…
Read moreGround-breaking software for modelling, simulation, optimization, estimation and validation applications in drug development timeline processes.
Thursday 16 October, 2025
Introduction: With the rapidly changing health care and research environments, it has become essential that the drug development process achieve…
Read moreImpact of Imbalanced Baseline Responses among Dose Levels in the Exposure-Response Analysis by Nonlinear Mixed-Effect Modeling
Thursday 16 October, 2025
Introduction: Dose-ranging clinical studies can encounter imbalanced baseline responses among the groups of subjects testing different dose levels of a drug,…
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