Thursday 16 October, 2025
Objectives: The use of Quantitative Systems Pharmacology (QSP) as part of the drug development process just keeps growing over the…
Read morePoster: Methodology - Other topics
Using preclinical data to predict human pharmacokinetics of monoclonal antibodies for first-in-human dose setting: A review of five internal case studies
Thursday 16 October, 2025
Introduction/Objectives: Therapeutic monoclonal antibodies (mAbs) have been a dominating class of new approved drugs during the last two decades. To determine…
Read moreAn asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies
Thursday 16 October, 2025
Introduction: Physiology-based pharmacokinetic (PBPK) models are being increasingly utilised in pharmacometrics to understand the whole-body disposition of various drugs. They…
Read moreAn asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies
Thursday 16 October, 2025
Introduction: Physiology-based pharmacokinetic (PBPK) models are important tools for understanding the distribution and clearance of drugs in organisms. Drugs may…
Read moreNumerical validation of Tucuxi, a promising new Bayesian adaptation tool
Thursday 16 October, 2025
Objectives: Therapeutic Drug Monitoring (TDM) is increasingly used in clinical practice to adjust dosage regimens based on specific patient characteristics…
Read moreOn the influence of sampling schemes on the demonstration of bioequivalence
Thursday 16 October, 2025
Objectives: Bioequivalence (BE) studies compare the concentration-time (C-t) profiles of two pharmaceutical products (test (T) and reference (R)) of the same…
Read moreDevelopment and validation of a population pharmacokinetic model for donepezil
Thursday 16 October, 2025
Objectives: Donepezil is a widely used drug for symptomatic relief of Alzheimer’s disease. Clinical trial data indicate high variability among…
Read moreLatexify.jl – An ecosystem for automatically transcribing Pumas and Julia objects into renderable equations.
Thursday 16 October, 2025
Objectives: The Julia programming language can represent, modify and execute its own code. This ability is powerful when defining domain-specific…
Read moreInvestigating the identifiability of one-stage IVIVC population models for extended-release dosage forms
Thursday 16 October, 2025
Objectives: In-vitro/in-vivo correlation (IVIVC) models can aid in the development of modified-release dosage forms such as extended-release (ER) products [1]….
Read moreEstimators and Confidence Intervals of f2 Using Bootstrap Methodology for the Comparison of Dissolution Profiles
Thursday 16 October, 2025
Introduction/Objectives: Dissolution tests are essential in the development of medicinal products. Among the multiple methods available to compare dissolution profiles,…
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