Thursday 16 October, 2025
Objective: RxODE is a new R package that facilitates straightforward PKPD simulation within R, providing an efficient and versatile way…
Read morePoster: Methodology - Other topics
A novel measure of importance of state variables for model reduction: results for the blood coagulation network
Thursday 16 October, 2025
Objectives: An increasing understanding of complex processes in biology and pharmacology has led to large-scale mechanistic models. These models, however, are…
Read moreDevelopment of a Physiologically-Based Pharmacokinetic Population Model for Pregnant Women
Thursday 16 October, 2025
Objectives: The goal of this study is to develop a physiologically-based pharmacokinetic (PBPK) model for the prediction of pharmacokinetics (PK) of…
Read moreAssembling pharmacometric datasets in R: the puzzle package
Thursday 16 October, 2025
Introduction: The pharmacometrics workflow has routine steps: 1) assemble the dataset, 2) explore, 3) model the data, 4) evaluate, 5)…
Read moreImaging procedures help compartmental analysis using nonlinear mixed effect models. Application in the field of non-clinical research.
Thursday 16 October, 2025
Objectives: A nonlinear mixed effect model is applied to solve a very sparse PK design where gammagraphic imaging was used…
Read moreMice with human livers improve First-in-Human prediction of pharmacokinetics
Thursday 16 October, 2025
Objectives: Over the last years, a new technology allowed the creation of chimeric mice with a humanized liver consisting of…
Read moreinVentR: a new flexible, powerful and efficient R package for model drug development using NONMEM®.
Thursday 16 October, 2025
Objectives: The pharmacometrician workflow can be summarized in five common steps: 1) build the dataset, 2) explore the data, 3)…
Read moreStructural and Practical Considerations in the Development of a Parent-metabolite Model
Thursday 16 October, 2025
Introduction: Issues often exist in parameter estimation of pharmacokinetic (PK) models for a parent drug and its metabolites. The model…
Read moreKIWI: a collaborative platform for modeling and simulation
Thursday 16 October, 2025
Objectives: Drug development programs rely increasingly on pharmacometric analysis to support decision-making and submissions to regulatory agencies[1,2]. To ensure high…
Read moreThe BAST Clinical Trial Simulator: A computational framework for quantitative risk assessment.
Thursday 16 October, 2025
Objectives: Recent years have witnessed the emergence of various Model Based Drug Development (MBDD) strategies all of which centre around a…
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