Thursday 16 October, 2025
Objectives: Probability of Pharmacological Success (PoPS) integrates knowledge of pharmacokinetics, pharmacodynamics and safety together with their uncertainty to quantify confidence…
Read morePoster: Methodology - Other topics
PECAN, a Shiny application for calculating confidence and prediction intervals for pharmacokinetic and pharmacodynamic models
Thursday 16 October, 2025
Objectives: Estimation accuracy for PK/PD or dose response models is typically reported as standard errors of the model parameters. However, for…
Read moreAutomatic translation of Bayesian pharmacometric models: the PharmML-to-WinBugs converter
Thursday 16 October, 2025
Objectives: PharmML is a markup language for pharmacometric models description, under development by the DDMoRe consortium, that will enable the…
Read moreModelling potential drug-drug interaction risks with a combined top-down/bottom-up approach
Thursday 16 October, 2025
Objectives: To develop a PK model combining the use of a top-down (non-linear mixed effects model) with a bottom-up (physiology-based pharmacokinetic…
Read moreMixed Effects Analysis of Non-compartmental Pharmacokinetic Parameters of Tofacitinib from 16 Phase 1 Studies.
Thursday 16 October, 2025
Objectives: Estimate and summarize effects of intrinsic and extrinsic factors on tofacitinib exposure, an oral Janus kinase inhibitor, in healthy adults…
Read moreStandardizing and accelerating data analysis and pharmacometric workflow with the PKPDmisc R toolkit.
Thursday 16 October, 2025
Objectives: In pharmacometrics, modelers are exposed to heterogeneous data analytic projects, including data preparation, analysis, simulation, and visualization. Though each project…
Read moreMatVPC: A User-friendly Matlab Tool for the Automatic Construction of Visual Predictive Checks and Quantified Visual Predictive Checks of Systems Pharmacology Models
Thursday 16 October, 2025
Objectives: Quantitative Systems Pharmacology (QSP) models are progressively entering the arena of contemporary pharmacology [1]. The efficient implementation and evaluation…
Read moreEvaluation of efficacy predictors and probability of pharmacological success for a novel compound to treat parasitic disease proposed for first-time-into-human
Thursday 16 October, 2025
Objectives: Parasitic diseases represent a global health problem. The development of new drugs for their treatment which facilitate compliance and…
Read moreTranslational pharmacology benchmarking of a novel drug candidate for an autoimmune disease
Thursday 16 October, 2025
Objectives: When assessing the probability of success of drugs with new mechanisms, it is important to understand the pharmacological requirement…
Read moreDevelopment and integration of the WinBUGS connector in the DDMoRe Interoperability Framework
Thursday 16 October, 2025
Objectives: The objective of our work is to develop and test a connector integrating WinBUGS [1] in the DDMoRe Interoperability Framework…
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