Thursday 16 October, 2025
Objectives: The objective of this study is to evaluate the relative performance of population compartmental method vs NCA (non-compartmental analysis)…
Read morePoster: Methodology - Other topics
Competitive landscape model using meta-analysis and simulation-based evaluation for Phase IIb study design of MRL-1 being developed for the treatment of rheumatoid arthritis
Thursday 16 October, 2025
Objectives: 1) To assess a competitive landscape for MRL-1 by comparing with market leaders and key competitors (disease-modifying antirheumatic drugs…
Read moreApproximate prediction percentiles for non-linear mixed effects models with continuous response
Thursday 16 October, 2025
Objectives: Prediction percentiles for non-linear mixed effect models are commonly calculated using a large number of Monte Carlo simulations. In some…
Read moreBuilding up a posteriori percentiles for Therapeutic Drug Concentration Monitoring
Thursday 16 October, 2025
Objectives: We propose to calculate a posteriori percentile curves (i.e. percentiles from the posterior predictive distribution of concentrations) for the rendering…
Read moreDevelopment of a New Mixed Poisson-Gaussian Model for Count Data from Rodent Brief-Access Taste Aversion Experiments
Thursday 16 October, 2025
Objectives: Rodent Brief-Access Taste Aversion (BATA) experiment is a common in-vivo screening tool to evaluate the taste of a drug…
Read moreIn-silico Biopharmaceutical Systems for Provisional Classification of Oral Drugs
Thursday 16 October, 2025
Classification of drug candidates based on the Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS) has…
Read moreCalling C functions from NONMEM
Thursday 16 October, 2025
Objectives: Some PK-PD modelling activities require the use of root finding techniques when an explicit solution of a function is…
Read moreTDMxR: an open-source package for model-based therapeutic drug monitoring in R
Thursday 16 October, 2025
Objectives: Pharmacometric models have gained popularity to support therapeutic drug monitoring (TDM) by model-based techniques such as ‘Probabilisting Dosing’, i.e….
Read moreAutomating pharmacometrics reporting using R Markdown
Thursday 16 October, 2025
Objectives: Pharmacometric analyses are used to streamline clinical drug development, and their reports are required as part of submission packages….
Read moreLaTeX-based report writing: 10 years’ experience from Sanofi’s M&S group in Germany
Thursday 16 October, 2025
Objectives: The writing of population analyses reports fulfilling the specifications of submission readiness is a time-consuming process and highly subjective to…
Read more