Thursday 16 October, 2025
Objectives: Optimal design of first time in human studies mainly relies on preclinical data for predicting drug exposure and pharmacodynamic effects….
Read morePoster: Methodology - New Modelling Approaches
In silico estimation of oral bioavailability: Implications to estimation of efavirenz PK parameters.
Thursday 16 October, 2025
Objectives: To develop methods/models that enable better predictions of pharmacokinetic parameter estimates. There is possible new way of modeling which…
Read moreThe prior subroutine explored: pharmacokinetic modeling of THC
Thursday 16 October, 2025
Objectives: To evaluate the Prior subroutine in NONMEM® by comparing model results after using a Prior versus the standard method…
Read moreEvaluation of random forest as an approach for covariate selection
Thursday 16 October, 2025
Objectives: Stepwise covariate modeling is a commonly used/accepted procedure for covariate search. This procedure consists of a forward inclusion followed…
Read moreModelling based methods to account for dropout in xenograft experiments
Thursday 16 October, 2025
Purpose: Xenograft studies are commonly used to assess the efficacy of new compounds and characterise their dose response relationship [1]. Analysis…
Read moreSimulation-based comparison of MMRM and dose-response MMRM for Ph2b dose-finding design in rheumatoid arthritis
Thursday 16 October, 2025
Introduction: The primary analysis of a Ph2b dose-finding study is typically based on pairwise statistical tests of the study arms, using…
Read morePharmpy and assemblerr – Two novel tools to simplify the model building process in NONMEM
Thursday 16 October, 2025
The development of pharmacometric nonlinear mixed effect models is a complex, multi-step process. Generally, it begins with an informed starting…
Read moreCharacterization of anti-drug antibodies using a bivariate mixed hidden Markov model
Thursday 16 October, 2025
Objectives: Monoclonal antibodies are a well-established therapy for several chronic inflammatory diseases. A phenomenon observed with administration of this type…
Read moreParameter Estimation in Bivariate Mixed Hidden Markov Models
Thursday 16 October, 2025
Objectives: Observable stochastic processes may depend on underlying hidden processes that can be modelled with mixed hidden Markov models (MHMMSs), allowing…
Read moreA Liver Model for Chemoprotection Against Malaria
Thursday 16 October, 2025
Introduction: Malaria is a deadly threat and to prevent its spread, it is important to protect people from infection, particularly…
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