Thursday 16 October, 2025
Objectives: Meta-analysis is a well-established methodology for combining the results of randomised controlled trials (RCTs) that compare the same treatments…
Read morePoster: Methodology - New Modelling Approaches
Finding underlying longitudinal patterns in pharmaco-metabolomics data
Thursday 16 October, 2025
Objectives: To develop a method that integrates multidimensional pharmaco-metabolomics data into a single PKPD systems pharmacology model in a data-driven manner,…
Read morePopulation PK/PD modeling of granocyte colony-stimulating factors given as single and repeated doses in healthy volunteers.
Thursday 16 October, 2025
Objectives: To develop a PK/PD population model to describe and compare the experimental observed profiles of two different formulations of lenograstim,…
Read moreInvestigation of Bayesian inference in predicting tissue concentrations using RStan
Thursday 16 October, 2025
Background & Objectives: A full PBPK model representing physiological profiles may not be available due to limited data. Minimal PBPK…
Read moreMethods and tools for multiscale modelling in Systems Pharmacology: a review
Thursday 16 October, 2025
Objectives: Systems Pharmacology aims to quantitatively study the dynamic interactions between drugs and biological systems by integrating models and data…
Read morePredictive assessments of pharmacokinetic alterations in subjects with renal disease
Thursday 16 October, 2025
Objectives: To find a model capable of predicting, relying on a minimum amount of PK information in normal subjects, the effect…
Read moreDose-response-time modelling – Second generation turnover model with integral feedback control
Thursday 16 October, 2025
Objectives: To demonstrate the utility of a dose-response-time (DRT) model using a large preclinical biomarker dataset of nicotinic acid (NiAc) induced…
Read moreComparison of the power and type-1 error of composite score models for drug effect detection in clinical trials
Thursday 16 October, 2025
Objectives: Many clinical trial endpoints are measured with composite scales which provide a measure of disease severity. A composite scale…
Read moreModeling & Simulation of Long-Term Body Weight Loss during Obesity Pharmacotherapy
Thursday 16 October, 2025
Objectives: Obesity pharmacotherapy can lead to clinically meaningful long-term body weight loss [1]. In early Proof-of-Concept studies, drug effects on…
Read moreFocusing on the essential dynamics of systems pharmacology models by exploiting an input-response characterisation
Thursday 16 October, 2025
Objectives: A growing understanding of complex biological processes has led to large-scale mechanistic, nonlinear models of pharmacologically relevant processes. These…
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