Thursday 16 October, 2025
Objectives: Effects of antibiotics on bacterial growth are typically modeled by a direct change of growth or death rate of a…
Read morePoster: Methodology - New Modelling Approaches
An exposure-response model relating nicotine plasma concentration to momentary craving across different nicotine replacement therapy formulations
Thursday 16 October, 2025
Objectives: Tobacco use is estimated to cause over 7 million avoidable deaths yearly [1] by increasing the risk of developing…
Read moreContribution of nonlinear mixed effects models and penalised regression approaches in pharmacogenetic population studies
Thursday 16 October, 2025
Context: Pharmacogenetics is now part of many clinical trials, in particular in population pharmacokinetic/pharmacodynamic (PK/PD) studies. Several methods are available…
Read moreUse of mixture models in pharmacometric model-based analysis of confirmatory trials: part I – simulation study evaluating type I error and power of proof-of-concept trials
Thursday 16 October, 2025
Objectives: Proof-of-concept studies (POC) are designed to eliminate inefficient drugs. Statistics underlying such decision are critical. Pharmacometric approaches based on…
Read morePK Precision Estimation to support the Design of a Pediatric Study of Belimumab Administered Subcutaneously
Thursday 16 October, 2025
Objectives: Belimumab (BENLYSTA) is a monoclonal antibody that binds to the B-lymphocyte stimulator protein and is currently approved for the…
Read moreSBPOP/mPD: Informing dose-concentration-response relationships – Application to study design and information generation based on competitor data
Thursday 16 October, 2025
Objectives: The main goal of quantitative approaches to drug development is the integration of all available information in order to…
Read moreExploring simplification of a target-mediated drug disposition (TMDD) model for bispecific antibodies for potential application to data-driven modelling
Thursday 16 October, 2025
Introduction: Bispecific antibodies are antibodies with two binding sites, directed against two different antigens or two different epitopes on the…
Read moreAn Industry Perspective on Extrapolation in Pediatric Drug Development: A Quantitative Approach to Assess Similarity of Adult and Pediatric Efficacy.
Thursday 16 October, 2025
Objectives: Recruitment of patients into pediatric studies is difficult and slow, and traditional fully powered pivotal trials are prohibitive. For…
Read moreDistributed transit compartments for arbitrary lifespan distributions in aging populations
Thursday 16 October, 2025
Objectives: In an aging population every individual has its own and unique lifespan, and after expiration the individual has to…
Read moreDevelopment and implementation of drug-drug interaction mechanisms with target-mediated drug disposition
Thursday 16 October, 2025
Objectives: We extend competitive, uncompetitive and non-competitive drug-drug interaction (DDI) mechanisms with target-mediated drug disposition (TMDD). We investigate quasi-equilibrium (QE)…
Read more