Thursday 16 October, 2025
Background and Objectives: Owing to the slow and variable progression of Parkinson’s disease (PD) symptoms, clinical trials aiming at identifying drug…
Read morePoster: Methodology - New Modelling Approaches
Methodology for Boolean Modeling of Biological Networks Applied to Systems Pharmacology
Thursday 16 October, 2025
Objectives: To provide an overview of the methodology to perform Boolean modeling in Systems Pharmacology, describing the required tools and steps…
Read moreAttractor analysis of Boolean models for Systems Pharmacology Networks
Thursday 16 October, 2025
Objectives: To provide an easy-to-use and efficient methodology to perform attractor analysis on Boolean models of Systems Pharmacology networks, guiding through…
Read moreACESO (A Cancer Evolution Simulation Optimizer)
Thursday 16 October, 2025
Objectives: The identification of drug administration schedules to avoid the emergence of resistance is a major challenge in cancer research….
Read moreEvaluation of the expected Fisher information matrix without linearization, in nonlinear mixed effect models for discrete and continuous outcomes
Thursday 16 October, 2025
Objectives: In recent years, estimation algorithms for NLMEMs have transitioned from linearization-based approaches towards more exact higher-order methods. Optimal design,…
Read moreItem Response Modeling to Leverage Data from Historical Parkinson’s Disease Trials while Integrating Data from a Newer Version of the Clinical Endpoint
Thursday 16 October, 2025
Objectives: Unified Parkinson’s Disease Rating Scale (UPDRS) has been used for assessing disease severity in Parkinson’s Disease (PD) trials for…
Read moreA workflow for application of the general pharmacodynamic interaction model on high-throughput combinatorial data in order to identify, quantify and characterise drug combinations that can overcome multi-drug-resistance
Thursday 16 October, 2025
Background: Antimicrobial resistance is one of the key challenges in the current global healthcare system [1]. As new antibiotics are…
Read moreItem Response Theory-Informed Total Score Analysis
Thursday 16 October, 2025
Objectives: Composite scales are commonly used in many disease areas, such as CNS disorders. Often these scales were developed for diagnosis,…
Read moreModelling UACR as a clinical endpoint
Thursday 16 October, 2025
Background: Urinary albumin-to-creatinine ratio (UACR) is a common biomarker for drugs in the renal space as an alternative to estimated…
Read moreIn-depth numerical model analysis tools to gain insight into model behavior of large-scale pharmacometric models
Thursday 16 October, 2025
Introduction: The development and application of pharmacometric models to describe and predict preclinical and clinical studies has become a routine…
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