Thursday 16 October, 2025
Introduction and objectives: According EMEA bioavailability means the rate and extent to which the active substance or active moiety is…
Read morePoster: Methodology - New Modelling Approaches
Bridging the gap between open and specialized modelling tools in PBPK/PK/PD with PhysPK/EcosimPro modelling system: PBPK model of methotrexate and 6-mercaptopurine in humans with focus in reusability and multilevel modelling features
Thursday 16 October, 2025
Objectives: To validate a novel modelling and simulation biomedical tool, PhysPK/EcosimPro, through the building of a MTX and 6-MP PBPK…
Read moreDevelopment of a semi-population deconvolution method for the analysis of growth hormone profiles
Thursday 16 October, 2025
Objectives: A major disadvantage of standard deconvolution techniques is that the variable time is not taken forward in the analysis….
Read moreComparison and selection of dosing regimens by discretization, optimizing efficacy and evaluating exposure demonstrated for KAE609 (Cipargamin)
Thursday 16 October, 2025
Objectives: Dosing regimen finding by discretization was formally proposed by D’Argenio in 1994 [1]. Here, we demonstrate an approach to…
Read moreA unified Rodgers et al. model for predicting tissue partitioning reveals the need for a theoretical derivation of the Lukacova et al. (Simulations Plus) model
Thursday 16 October, 2025
Objectives: The a priori prediction of tissue partitioning constitutes a core element of physiologically-based pharmacokinetic modelling. There exist a number…
Read moreTarget-mediated drug-disposition (TMDD) model comparison using the MonolixSuite
Thursday 16 October, 2025
Objectives: The increase of biologic drugs in development leads to a rise of the use of target-mediated drug disposition (TMDD) models…
Read moreA novel model-integrated design for bioequivalence of long acting injectables
Thursday 16 October, 2025
Objectives: Long-acting injectables (LAI) have been developed to offer prolonged drug release and thus improve treatment adherence. Approximately 30 LAI…
Read moreMathematical modeling by random ordinary differential equations and their numerical schemes
Thursday 16 October, 2025
Objectives: Random ordinary differential equations (RODEs) are introduced to build mathematical models with noise processes. Numerical schemes for RODEs are developed…
Read moreMixed-effects ARX model identification of dynamical systems
Thursday 16 October, 2025
Objectives: With the advent of realtime biotechnologies, most of biological responses measured during in-vitro or in- vivo experiments exhibit non-linear behaviors…
Read moreThe reference corrected VPC – A more intuitive model diagnostic
Thursday 16 October, 2025
Background:The prediction corrected visual predictive check (pcVPC) is an informative model diagnostic that offer advantages over regular VPCs, in particular…
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