Thursday 16 October, 2025
Objectives: Artemether-lumefantrine (AL) and nevirapine (NVP) are currently the most widely recommended antimalarials and antiretrovirals in Africa.[1] Artemether (AM) is…
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Population Pharmacokinetics of Cefoxitin as a Prophylactic Antimicrobial Agent
Thursday 16 October, 2025
Objectives: The aim of this study was to develop a population pharmacokinetic (PPK) model of cefoxitin (FOX) as a prophylactic…
Read morePopulation PK of Isoniazid in South African Adults.
Thursday 16 October, 2025
Objectives: Isoniazid, together with rifampicin, forms the backbone of 1st line antitubercular treatment. The rate of isoniazid metabolism is highly…
Read morePopulation pharmacokinetics of ritonavir-boosted darunavir together with efavirenz in healthy volunteers
Thursday 16 October, 2025
Objectives: Ritonavir-boosted darunavir (DRV/r) with efavirenz (EFV) is an alternative nucleoside-sparing regimen for HIV treatment. The metabolic pathways involved in the…
Read moreMethods for Optimising Neonatal Antimicrobial Use: Time- and Concentration-Dependent Agents
Thursday 16 October, 2025
Objectives: Pharmacokinetic studies in neonates are increasingly common; it is important their results are used rationally. This study arose from…
Read moreExtensive Population Pharmacokinetic-Pharmacogenetic Study of Nevirapine in HIV-Infected Cambodian Patients
Thursday 16 October, 2025
Objectives: Focused genotyping of CYP2B6 516G/T in HIV-infected Cambodians in the ANRS12154 study showed its association with steady-state NVP clearance…
Read morePopulation Pharmacokinetic-Pharmacogenetic study of Efavirenz in combination with anti-TB treatment in HIV-Infected Cambodian Patients
Thursday 16 October, 2025
Objectives: To monitor efavirenz plasma concentrations in Cambodian patients of the CAMELIA-ANRS1295-CIPRA KH001 trial and to explore genetic variations as…
Read morePharmacokinetics of tobramycin do not differ in patients with and without cystic fibrosis
Thursday 16 October, 2025
Objectives: While several studies have examined the pharmacokinetics (PK) of tobramycin in patients with cystic fibrosis (CF) (1-3), there is…
Read morePK/PD Indices of Antibiotics Predicted by Mechanism-Based PKPD Models
Thursday 16 October, 2025
Objectives: Currently used dosing regimens of antibiotics are generally based on summary endpoints. One of three PK/PD indices (Cmax/MIC, AUC/MIC,…
Read moreTarget Attainment Analysis to Evaluate Dosing Regimens of an Oral β-Lactam Antibioic
Thursday 16 October, 2025
Objectives: In lack of data supporting mechanism-based PKPD modeling, the selection of dosing regimens within the infectious disease area is…
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