Thursday 16 October, 2025
Objectives: AZD9773 is an intravenously infused ovine-derived polyclonal anti-TNF-α Fab fragment currently being developed as a treatment for severe sepsis….
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Modelling the impact of fecal ciprofloxacin concentrations on fecal counts of resistant Enterobacteriaceae in piglets treated with ciprofloxacin: towards new means to control the spread of resistance?
Thursday 16 October, 2025
Objectives: The colonic flora is where antibiotic residues select resistant commensal bacteria during treatment [1]. In this prospective randomised study…
Read morePharmacokinetic-Pharmacodynamic Modelling of Pre-existing and Emerging Resistance of Pseudomonas aeruginosa to Colistin
Thursday 16 October, 2025
Objectives: In recent years, colistin has gained popularity as a last resort antibiotic in the battle against resistant bacteria. Pseudomonas…
Read morePopulation modelling of the pharmacokinetics of a mefloquine-artesunate treatment at the Thai-Myanmar border
Thursday 16 October, 2025
Background: Malaria is an important health problem in tropical regions of the world. Artesunate-mefloquine is a standard treatment against Plasmodium falciparum…
Read morePharmacokinetic/pharmacodynamic Modeling and Long-term Simulation of Dolutegravir (DTG, S/GSK1349572) in Integrase Resistant Patients with a Simple Viral Dynamic Model
Thursday 16 October, 2025
Objectivr: DTG is an unboosted, once daily integrase inhibitor (INI) currently under development for the treatment of HIV infection. Effectiveness…
Read morePopulation Pharmacokinetics/Pharmacodynamics of Ampicillin/Sulbactam in Patients with Moderate or Severe Community-Acquired Pneumonia
Thursday 16 October, 2025
Introduction and Objectives: Unasyn® (injectable combination of sulbactam sodium and ampicillin sodium, dose ratio 1:2) has been marketed over 60…
Read moreAssessment of dosage regimens of tigecycline in hospitalised patients
Thursday 16 October, 2025
Objectives: To study various dose regimens of the antibiotic tigecycline in a group of hospitalised patients and assess the potential…
Read moreThe population pharmacokinetic and pharmacodynamic properties of intramuscular artesunate and quinine in Tanzanian children with severe falciparum malaria; implications for a practical dosing regimen.
Thursday 16 October, 2025
Objectives: Parenteral artesunate is the drug of choice for treatment of severe malaria. The pharmacokinetic properties of intramuscular artesunate have…
Read moreComparison of Four Renal Function Estimator-Based Models for the Prediction of Gentamicin Concentrations in Geriatric Patients by Use of Nonparametric Population Approach
Thursday 16 October, 2025
Objectives: Most aminoglycoside pharmacokinetic models include an index of renal function, such as creatinine clearance to describe elimination [1]. However,…
Read moreIntegrated Population Pharmacokinetic Model Development of Nevirapine for Mothers and Newborns including Healthy Male Volunteer Data
Thursday 16 October, 2025
Objectives: A population pharmacokinetic (PK) model of nevirapine (NVP) was developed to describe the population PK of NVP after single…
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