Thursday 16 October, 2025
BackgroundBispecific therapeutics have emerged as a promising class due to their ability to target two distinct antigens simultaneously, resulting in…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Long-acting formulation drug-drug interactions: evaluating the importance of timing using a subcutaneous levonorgestrel PBPK example
Thursday 16 October, 2025
Introduction: Long-acting drug formulations, such as injectables or subcutaneous implants, can provide significant benefits for drugs being taken for long…
Read moreIndividualized Tacrolimus dosing in pediatric kidney transplantation: identification of new genomic, proteomic and metabolomic biomarkers and PhysPK® development of PBPK-based predictive models, simulations and applications in different phamacogenomic subpopulations.
Thursday 16 October, 2025
Objectives: Tacrolimus (TCR) is the primary immunosuppressive (IS) drug used in pediatric kidney transplantation. As other IS, TCR presents a high…
Read moreTranslational physiologically based pharmacokinetic modeling to predict human pulmonary kinetics after inhalation
Thursday 16 October, 2025
Objectives: Oral inhalation is an attractive approach for drug delivery, especially when targeting respiratory diseases. Inhalation provides a rapid onset…
Read moreUnlocking Diversity: Towards a Comprehensive Framework for Physiologically Based Pharmacokinetic Population Qualification in Sub Saharan Africa
Thursday 16 October, 2025
Objectives: Characterize a population Gather CYP450 enzyme activity phenotype data from SSA Subdivision of SSA into regions and statistically compare…
Read moreBuilding a physiologically-based pharmacokinetic model for a carcinogenic food contaminant aflatoxin B1
Thursday 16 October, 2025
Objectives: Building a PBPK-model for AFB1 Validation of the developed substrate file with human in vivo data Application of the…
Read morePBPK modeling based clinical dose adaptation in liver cirrhosis patients for seven CYP and UGT enzyme substrates
Thursday 16 October, 2025
Introduction: In patients with impaired liver function, understanding the pharmacokinetics (PK) is crucial for effective and safe medication management. Liver…
Read moreA physiologically-based pharmacokinetic model for prediction of cannabidiol pediatric dose
Thursday 16 October, 2025
Objectives: To develop a PBPK model for CBD to predict age-dependent pediatric dosage regimens by modifying a previously PBPK model…
Read moreDevelopment of a physiologically-based pharmacokinetic model to understand and predict the disposition of gallium-68 radiolabeled-dendrimers in vivo
Thursday 16 October, 2025
Introduction/Objectives: In the past twenty years, numerous diverse nanoparticles (NPs) have been designed in order to improve the pharmacokinetic (PK) profile…
Read morePK and PBPK modeling approaches to describe the lung and systemic exposure after inhalation of AZD4604
Thursday 16 October, 2025
Objectives: AZD4604 is an inhaled JAK1 selective inhibitor being developed for treatment of moderate to severe asthma [1]. AZD4604 is…
Read more