Thursday 16 October, 2025
Replacing animal testing by in silico and in vitro methods is crucial for ethical and sustainable drug development. Physiology Based…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Systemic and ocular physiologically based pharmacokinetic models for protein therapeutics in rabbits
Thursday 16 October, 2025
Objectives: Rabbits play a pivotal role as a highly valued small animal model, particularly in the field of ocular therapeutics, where…
Read moreDevelopment of a PBPK model to predict monoclonal antibody pharmacokinetics and bioavailability following subcutaneous administration
Thursday 16 October, 2025
Introduction: Monoclonal antibodies (mAbs) are currently established components of oncology and immunology therapies, typically administered intravenously over extended treatment periods of…
Read moreAn Integrated PBPK-Quantitative Systems Pharmacology Model for Statins to Assess the Variability and Implications of Transporter-Mediated Distribution
Thursday 16 October, 2025
Introduction: Quantitative Systems Pharmacology (QSP) models can be used to quantitatively and mechanistically describe the underlying biological/pharmacological processes in disease….
Read morePBPK model-based extrapolation from adults to children to predict furosemide oral solution bioavailability
Thursday 16 October, 2025
Introduction Furosemide is a loop diuretic that has been used in adults and children for decades, mainly for the treatment…
Read morePopulation analysis of the in vivo pharmacokinetic characteristics of a letrozole sustained delivery formulation in Beagle dogs
Thursday 16 October, 2025
Introduction/Objectives: Letrozole is an aromatase inhibitor that is currently marketed as oral tablets as a first line treatment for hormone-dependent…
Read morePhysiologically based Pharmacokinetic and Pharmacodynamic modeling of Enzalutamide and N-desmethyl enzalutamide
Thursday 16 October, 2025
Objectives: Enzalutamide (ENZ) is a second-generation androgen receptor inhibitor used in the treatment of castration-resistant prostate cancer (CRPC). The clinical…
Read moreOcular Exposure Extrapolation Across Multiple Species Using PBPK Modeling and Simulation: Latanoprost Solution Case Study
Thursday 16 October, 2025
Objectives: Glaucoma is a disease that damages the optic nerve, leading to vision loss. In most cases, it is caused…
Read moreDevelopment of a physiological-based pharmacokinetic model for sacubitril and its metabolite
Thursday 16 October, 2025
Objectives: Sacubitril/valsartan, a novel angiotensin receptor neprilysin inhibitor, has been approved for chronic heart failure treatment to reduce the risk…
Read moreOral absorption modeling of weakly basic drugs – Combining in vitro and in silico models
Thursday 16 October, 2025
Introduction: During formulation development of weakly basic drug candidates, special attention should be paid to potential drug precipitation during gastrointestinal…
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