Thursday 16 October, 2025
Introduction: Polycystic ovary syndrome (PCOS) is one of the major causes of female infertility, which affects about 15-20% of couples…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
A Physiologically Based Pharmacokinetic Model of Atorvastatin Acid Predicting CYP3A4 and OATP1B Drug–Drug Interactions
Thursday 16 October, 2025
Introduction: The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor atorvastatin is a widely prescribed statin for managing dyslipidemia, a well-established risk factor…
Read moreEstimation of a sensitive range of dose-adjusted FaSSIF solubility to predict the food effect on BCS II/IV drugs
Thursday 16 October, 2025
Introduction: The simultaneous administration of oral dosage forms with food can have a significant impact on drug pharmacokinetics [1]. Physiologically…
Read morePhysiologically-based pharmacokinetic model for itraconazole and its metabolites: the importance of parameter sensitivity analysis
Thursday 16 October, 2025
Introduction: : Itraconazole has emerged as one of the best candidates to use as a standard CYP3A4 inhibitor in clinical…
Read moreSimvastatin disposition described by physiologically based pharmacokinetics: Does choice of applied PBPK platform matter?
Thursday 16 October, 2025
Introduction/Objectives: The use of complex whole-body physiologically-based pharmacokinetic (PBPK) models in drug discovery and development is facilitated by the development…
Read moreHow to improve the accuracy of Drug-Drug Interaction risk prediction for Mechanism Based Inhibitors
Thursday 16 October, 2025
Objectives:Mechanism-based inhibition (MBI) is a subtype of enzymatic inhibition in which the enzyme is permanently inactivated by an intermediate reactive…
Read moreAssessment of bioequivalence outcomes of oral formulations containing racemic ibuprofen through a chiral physiologically-based pharmacokinetic model
Thursday 16 October, 2025
Introduction: The characterization of the time course of ibuprofen (IBU) enantiomers can be useful in the selection of the most sensitive…
Read moreChirality matters: physiologically based pharmacokinetic modelling of ibuprofen enantiomers
Thursday 16 October, 2025
Introduction/Objective: Ibuprofen is a non-steroidal anti-inflammatory drug administered in its racemic form containing equal amounts of R-ibuprofen (pharmacologically inactive) and S-ibuprofen…
Read moreA Physiologically Based Pharmacokinetic Model for Open Acid and Lactone Forms of Atorvastatin and Its Two Metabolites
Thursday 16 October, 2025
Introduction: Atorvastatin (ATS), one of the most prescribed statin worldwide, shows low oral bioavailability and non-linear pharmacokinetics (PK) due to its…
Read morePhysiologically Based Pharmacokinetic Model for Atorvastatin: New Insights in Enzymatic and Transport Processes.
Thursday 16 October, 2025
Introduction: Atorvastatin (ATS) is one of the most frequently prescribed 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase reversible inhibitors, also known as…
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