Thursday 16 October, 2025
Objectives: Physiologically based pharmacokinetic (PBPK) models can be used to conduct virtual bioequivalence (VBE) studies. There are different ways to input…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
In Silico Dosimetry Study of Tc99m-Tetrofosmin in Children Using a Novel PBPK Model in Humans Built from SPECT Imaging Data
Thursday 16 October, 2025
Introduction: The aim of this work is to develop a Physiologically Based Pharmacokinetic model (PBPK) for the radiopharmaceutical Tc99m-Tetrofosmin in humans,…
Read morePopulation pharmacokinetic modelling for enterohepatic circulation of leflunomide in healthy Korean
Thursday 16 October, 2025
Objectives: Leflunomide is an immunosuppressive drug indicated for the treatment of rheumatoid arthritis (RA). Leflunomide is characterized by high protein…
Read moreA paradigm shift in oral drug absorption: The rise of physiologically based finite time pharmacokinetic (PBFTPK) models.
Thursday 16 October, 2025
Objectives: To explore the application of the parameters of the physiologically based finite time pharmacokinetic (PBFTPK) models (1) subdivided in first-order…
Read moreDevelopment of a Physiological-Based Pharmacokinetic Model for Ritonavir: Unraveling its Triphasic Effects as CYP3A Inhibitor, CYP3A Inducer, and Pgp Inhibitor.
Thursday 16 October, 2025
Introductions: Ritonavir (RTV) was originally approved for the treatment of human immunodeficiency virus (HIV) infection. Currently, the drug is no…
Read moreCharacterization of absorption kinetics of oral esketamine in healthy volunteers
Thursday 16 October, 2025
Objectives: The interest in esketamine as antidepressant drug remains high ever since it first got registered as an option for…
Read moreA Physiologically Based Pharmacokinetic (PBPK) Model of Sildenafil to Predict Exposure in Pregnant Females. What is missing?
Thursday 16 October, 2025
Objectives: Sildenafil (S), a potent vasodilator, has recently been shown to reduce the incidence of operative delivery for intrapartum fetal compromise…
Read morePredicting the impact of healthy aging on the brain pharmacokinetic profiles using a translational modeling approach
Thursday 16 October, 2025
Objectives: Unbound drug concentrations at brain extracellular (ECF) and intracellular (ICF) target sites are the drivers of CNS drug (side)…
Read moreExploring the impact of obesity on drug clearance using PBPK modelling approaches: influential variables affecting scaling from non-obese to obese subjects for drugs metabolized in the liver
Thursday 16 October, 2025
Objectives: Determining drug clearance (CL) is important to establish drug dosing. In the obese, some drugs do not show any…
Read morePhysiologically Based Pharmacokinetic Modeling of Dasatinib to Describe Enzyme-Mediated and pH-Dependent Drug–Drug Interaction Scenarios
Thursday 16 October, 2025
Introduction: The clinical application of dasatinib – a second-generation tyrosine kinase inhibitor – in the treatment of chronic myeloid leukemia is…
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