Thursday 16 October, 2025
Objective: To develop a pharmacokinetic (PK) model of nevirapine (NVP) in African children accounting for the effect of CYP2B6 polymorphisms…
Read morePoster: Drug/Disease modeling - Paediatrics
Evaluation of tetrahydrobiopterin responsiveness in neonates with hyperphenylalaninemia
Thursday 16 October, 2025
Objectives: Hyperphenylalaninemia (HPA) is the most common dysfunction of metabolism of amino acids, caused by a missing or reduced activity of…
Read moreA population pharmacokinetic analysis of once-daily intravenous busulfan in pediatric patients undergoing hematopoietic stem cell transplantation
Thursday 16 October, 2025
Objectives: Busulfan is a bifunctional alkylating agent, which is indicated for use in combination with cyclophosphamide as a conditioning regimen…
Read moreAge influence on clearance of phenobarbital in paediatric patients
Thursday 16 October, 2025
Objectives: To describe the influence of AGE on phenobarbital clearance (CL/FPBT) developing a pharmacokinetic (PK) model in a paediatric population. …
Read morePopulation modeling of cytochrome P450 mediated drug metabolism and oral absorption in preterm neonates receiving intravenous and oral midazolam in a cross-over study
Thursday 16 October, 2025
Objectives: Midazolam is a benzodiazepine which is often used for sedation in neonatal and pediatric intensive care units orally or…
Read morePredictive performance of a CRP and organ failure based pharmacokinetic model for midazolam in critically ill children across external datasets in neonates, children and adults
Thursday 16 October, 2025
Objectives: Midazolam is often used for sedation in pediatric intensive cares and for surgical procedures. A recent study quantified the…
Read moreSimulations of vancomycin exposure throughout childhood upon commonly used dosing guidelines: towards a model-based dosing regimen
Thursday 16 October, 2025
Objectives: Despite many reports on the pharmacokinetics of vancomycin in children, target concentrations of vancomycin in daily practice are difficult to…
Read morePopulation pharmacokinetic analysis of lamivudine in children aged 5 months – 18 years
Thursday 16 October, 2025
Objectives: Lamivudine is a nucleoside reverse transcriptase inhibitor and used as part of antiretroviral therapy in HIV-infected children. A population pharmacokinetic…
Read moreUse of semi-physiological covariate model for maturation of glucuronidation to scale from adults to children
Thursday 16 October, 2025
Objectives: A semi-physiological covariate model describing the glucuronidation clearance (Clgluc) of morphine in young children was successfully applied to model…
Read moreAllometric scaling of clearance in paediatrics: when does the magic of 0.75 fade?
Thursday 16 October, 2025
Objectives: Allometric scaling on the basis of bodyweight raised to the power of 0.75 (AS) [1] is frequently used to…
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