Thursday 16 October, 2025
Objectives: To investigate designing a pharmacokinetic (PK) study using adult prior information for a case-study on mefloquine and to evaluate…
Read morePoster: Drug/Disease modeling - Paediatrics
Building of a virtual paediatric cancer population for physiologically-based pharmacokinetic modelling and simulation in neonates, infants, and children
Thursday 16 October, 2025
Objectives: Determination of appropriate dosing of many anticancer agents in neonates and infants is a difficult task. Doses are routinely…
Read moreOmeprazole dose recommendation in pediatric patients aged 1-11 months with erosive esophagitis
Thursday 16 October, 2025
Objectives: Omeprazole (PRILOSEC) 20mg once daily is approved in the US for adults with gastroesophageal reflux disease and erosive esophagitis….
Read moreDosing recommendation for gabapentin in chronic paediatric pain
Thursday 16 October, 2025
Objectives:The main objective of this analysis is to identify an exposure range for gabapentin that can be used as target…
Read moreComparison of current dose-reduction schemes for doxorubicin in young children using a recently developed population pharmacokinetic model
Thursday 16 October, 2025
Objectives: Knowledge on the pharmacokinetics (PK) of doxorubicin, especially in very young children (<2 years), is extremely limited. As doxorubicin…
Read moreDose Recommendations for Recombinant Asparaginase in Children: A Population Pharmacokinetic Analysis
Thursday 16 October, 2025
Objectives: The enzyme Asparaginase is used for remission induction and post-induction treatment in acute lymphoblastic leukemia. A new recombinant E.coli-Asparaginase…
Read moreA Prospective Population Pharmacokinetic (PK) Analysis of Sapropterin Dihydrochloride in Infants and Young Children with Phenylketonuria (PKU)
Thursday 16 October, 2025
Objectives: To determine the appropriate dose of sapropterin dihydrochloride, a synthetic preparation of naturally occurring phenylalanine hydroxylase (PAH) cofactor tetrahydrobiopterin (BH4),…
Read moreMechanistic modelling of naive CD4+ T cell homeostasis in HIV-infected children on anti-retroviral therapy
Thursday 16 October, 2025
Objectives: The overall aim of this work is to develop a differential equations model to facilitate understanding of the changes taking…
Read moreImpact of Hepatitis C coinfection on Immune reconstitution in HIV-infected children undergoing therapy
Thursday 16 October, 2025
Objectives: The effect of HCV co-infection on CD4 T cell recovery in treated HIV-infected children is poorly understood. The main…
Read morePopulation Pharmacokinetic/Pharmacogenetic Analysis of Nevirapine in African Children
Thursday 16 October, 2025
Objectives: Nevirapine is a NNRTI widely used for treatment of HIV-infected adults and children. It is metabolised by CYP3A4 and CYP2B6…
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