Thursday 16 October, 2025
Objectives: Recent research indicates that dynamics of gastric emptying may be different in obese and non-obese adults and can affect…
Read morePoster: Drug/Disease modeling - Endocrine
Target validation and lead optimization in drug development for diabetes using a physiologically-based PK/PD model of the glucose-insulin regulatory system
Thursday 16 October, 2025
Objectives: Realistic in-silico models of the glucose metabolism are valuable tools in diabetes research, drug development and development of treatment…
Read moreTranslational modelling of prolactin response following administration of D2 antagonists in rats
Thursday 16 October, 2025
Objectives: Treatment with D2 antagonists results in prolactin release, and thus prolactin is a biomarker of dopamine antagonism. We compare the…
Read moreGlucose Homeostasis Modeling: Improvement of the Insulin Kinetics Component
Thursday 16 October, 2025
Objectives: Models of glucose homeostasis are important for the development of anti-diabetic drugs. Several models have been developed (e.g. [1]); however,…
Read moreModel for characterizing copeptin kinetics and response in healthy volunteers
Thursday 16 October, 2025
Objectives: Vasopressin, a neurohypophysal hormone, is used in clinic to diagnose diabetes insipidus. Copeptin is evaluated as a new biomarker…
Read moreEvaluating the clinical influence of UGT2B15 genotype on the pharmacodynamic response of the PPAR agonist, sipoglitazar
Thursday 16 October, 2025
Objectives: Sipoglitazar, a pan-PPAR agonist was targeted for treating type 2 diabetes (T2D). Sipoglitazar undergoes conjugation catalyzed by UGT.1 UGT2B15…
Read moreComparison of post-prandial glucose control by two GLP-1 receptor agonists (lixisenatide and liraglutide) in type 2 diabetes
Thursday 16 October, 2025
Objectives: To develop mechanistic meal test models for lixisenatide, a short-acting prandial GLP-1 receptor agonist [1], and liraglutide, a long-acting one,…
Read moreSupport phase II dose selection of a novel dual GIP/GLP-1agonist using a population PKPD model developed on phase I data
Thursday 16 October, 2025
Objectives: The objective of the analyses was to support the Phase II dose selection through the characterization of the non-linear…
Read moreTranslational modelling of regular human insulin pharmacokinetics and glucose dynamics in minipig and dog
Thursday 16 October, 2025
Objectives: To develop a foundational framework for the extrapolation of insulin kinetics and glucose dynamics from preclinical animal models to…
Read moreApplication of a Semi-Mechanistic, Integrated Glucose-Insulin Model to Graded Glucose Infusion Placebo Data to translate Glucose Insulin dynamics between Healthy Humans and Non-Human Primates
Thursday 16 October, 2025
Objectives: To develop a foundational framework for the extrapolation of novel drug effects observed in non-human primates (NNP) to healthy volunteers…
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