Thursday 16 October, 2025
Objectives: Hyperglycemia is generally associated with an increased intracellular generation of reactive oxygen species (ROS) and oxidative stress. ROS may, in…
Read morePoster: Drug/Disease modeling - Endocrine
Modelling of glucose-insulin metabolism and its effect on the estrous cycle in bovine
Thursday 16 October, 2025
Objectives: To develop a mechanistic mathematical model of glucose-insulin and to investigate its effect on the dynamic of the hormonal…
Read moreAn Integrated Model for Glucose and Insulin Regulation in Bariatric Surgery Patients following Intravenous Glucose Tolerance Test
Thursday 16 October, 2025
Objectives: Gastric Bypass Surgery (GBS) is a common treatment option for severe obesity. GBS induces weight loss but also improves glucose…
Read moreModel-based Meta-analysis for Development of a Population-Pharmacokinetic (PPK) Model for Vitamin D3 and its 25OHD3 Metabolite
Thursday 16 October, 2025
Objectives: Association of Vitamin D3 (D3) and its metabolite (25OHD3) exposure with various diseases, including bone health, diabetes, and cancer,…
Read moreImportance of hot glucose for the integrated glucose-insulin minimal model
Thursday 16 October, 2025
Background and Objectives: An Integrated minimal model (IMM) has been proposed by Largajolli et al. to characterize simultaneously glucose-insulin regulation…
Read moreQuantifying drug effects in phase 2a anti-diabetic studies: Power and accuracy of four HbA1c models
Thursday 16 October, 2025
Background and Objectives: Several dynamic models of HbA1c have been suggested for the analysis of anti-diabetic study data: FPG-FSI-HbA1c (FFH) [1],…
Read moreCarbohydrate intake contribution to HbA1c
Thursday 16 October, 2025
Objectives: To investigate the impact of different carbohydrate intakes to HbA1c for well-controlled and uncontrolled patients with type 2 diabetes…
Read moreEffect of Fluticasone Furoate Treatment on Cortisol Circadian Rhythm in Healthy Chinese Subjects
Thursday 16 October, 2025
Objectives: Fluticasone furoate (FF) is a novel corticosteroid with potent glucocorticoid activity. It has being developed as a potential steroid…
Read moreMetformin’s glucose lowering effect in healthy volunteers receiving an oral glucose tolerance test
Thursday 16 October, 2025
Objectives: Although metformin is a widely used for the treatment of type II diabetes mellitus, only a few articles have reported…
Read moreModeling HbA1c dynamics in type II diabetes mellitus in patients treated with GLP-1 receptor agonist lixisenatide
Thursday 16 October, 2025
Objectives: To extend a recently published disease progression [1] model for lixisenatide, a prandial GLP-1 receptor agonist [2], in order…
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