Thursday 16 October, 2025
Objectives: Silber et. al1 published an integrated glucose-insulin (IGI) model, describing glucose and insulin after various glucose loads in healthy subjects and…
Read morePoster: Drug/Disease modeling - Endocrine
Are insulin measurements needed in glucose provocation studies? : Comparison of study power using Monte-Carlo Mapped Power (MCMP) method
Thursday 16 October, 2025
Objectives: Most glucose provocation studies are performed according to standard protocols, but the needs for insulin measurements have been questioned when…
Read moreLinking mechanism-based modelling of type 2 diabetes mellitus with cardiovascular endpoints
Thursday 16 October, 2025
Objectives: Type 2 diabetes mellitus (T2DM) is by insulin resistance and deficient insulin secretion by pancreatic beta cells. Antidiabetic medications are…
Read moreDose-concentration-response modelling of inhibin B in controlled ovarian stimulation with FE 999049, a recombinant FSH derived from a human cell-line
Thursday 16 October, 2025
Objectives: A recombinant follicle stimulating hormone (FSH) expressed from a cell-line of human fetal retinal origin (PER.C6®), FE 999049, is currently…
Read moreSemi-mechanistic modelling of the nonlinear hydrocortisone pharmacokinetics to enable extrapolation into paediatric patients
Thursday 16 October, 2025
Objectives: Therapy optimisation of hydrocortisone (HC), synthetic cortisol, is challenging due to its nonlinear pharmacokinetics (PK) caused by several factors:…
Read moreInterspecies scaling of the integrated glucose insulin model
Thursday 16 October, 2025
Background and objective: The integrated glucose insulin (IGI) model is a semi-mechanistic model that describes glucose and insulin concentrations in…
Read morePharmacodynamics of the renin-angiotensin aldosterone system and blood pressure in relation to food intake in dogs
Thursday 16 October, 2025
Objectives: Similar to humans, activation of the renin-angiotensin-aldosterone system (RAAS) is one of the key neurohumoral responses to the reduced cardiac…
Read moreAcute tolerance and rebound modelling with competitive interaction of mineralcorticoid driven urinary sodium excretion effects in the rat
Thursday 16 October, 2025
Objectives: Mineralcorticoid receptor (MR) antagonism prevents the endogenous agonist aldosterone to retain sodium to be excreted in urine. The objective…
Read moreModelling of Glucose and Insulin profiles in Patients with Type 2 Diabetes Mellitus treated with a GLP-1 analogue
Thursday 16 October, 2025
Objectives: In recent years several Glucagon-like peptide-1 (GLP-1) based therapies for the treatment of type 2 diabetes mellitus (T2DM) have been…
Read moreModelling the disease progression of diabetes from healthy to overtly diabetic in ZDSD rats
Thursday 16 October, 2025
Objectives: Type 2 diabetes (T2DM) is a disease exhibiting a gradual worsening of hyperglycemia, on the timescale of years. Studying…
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