Mohamed Omari, Julia Plöntzke, Mascha Berg, Susanna Röblitz
Zuse Institut Berlin (ZIB), Takustr. 7, 14195 Berlin
Objectives: To develop a mechanistic mathematical model of glucose-insulin and to investigate its effect on the dynamic of the hormonal cycle in dairy cows.
Methods: A mechanistic mathematical model of glucose-insulin is developed based on the biological knowledges and experimental data [1,2,3]. The mathematical model describes the dynamical behaviour of insulin and glucose in the blood and in the tissues under different diet fractions. This model is linked to the bovine hormonal cycle that has been developed earlier in our group [4,5]. The model simulates periodic estrous cycles lasting 21 days, describing the dynamic of follicles, the corpus luteum and the key reproductive hormones regulating the system.
Results: Simulation results show that the glucose-insulin model is able to simulate reasonably the dynamics of the glucose and insulin within their physiological ranges under different diet regimen of the dry matter intake. In addition, by linking this model to the bovine estrous cycle, a selected diet restrictions show to cause an effect on the key reproductive hormones regulating the cycle, in particular an effect on the follicular development.
Conclusions: Formulating a mathematical model that simulates the effect of metabolic factors on bovine fertility will improve our understanding on the underlying biological processes without the need for new animal experiments and thereby assist in developing strategies again declined fertility in dairy cows.
References:
[1] CK Reynolds, Florida ruminant nutrition symposium, 143-154 (2005).
[2] JM Berg, JL Tymoczko, L Stryer, Biochemistry, WH Freeman, 5th edition Chapter 21, Glycogen Metabolism, (2002).
[3] R Pfuhl, O Bellmann, C Kuhn, F Teuscher, K Ender, J Wegner, Archiv für Tierzucht 50(1), (2007).
[4] HMT Boer, C Stötzel, S Röblitz, P Deuflhard, RF Veerkamp and H Woelders, J. Theor. Biol. 278, 20–31 (2011).
[5] C Stötzel, J Plöntzke, W Heuwieser, and S Röblitz, Theriogenology 78(7), 1415–1428 (2012).
Reference: PAGE 25 (2016) Abstr 5822 [www.page-meeting.org/?abstract=5822]
Poster: Drug/Disease modeling - Endocrine