Thursday 16 October, 2025
Objectives: Amount of opioid (eg. morphine) required by patients after surgery is often used as a surrogate measure for pain intensity…
Read morePoster: Drug/Disease modeling - CNS
Exploring the relationship between analgesic event rate and pain intensity in kidney stone surgery: A Repeated Time to Event Pilot Study
Thursday 16 October, 2025
Objectives: Opioid consumption has often been reported as an indirect measure of pain in postoperative pain trials. The rate of consecutive…
Read morePopulation pharmacokinetics of NNZ-2566 in healthy subjects and Rett syndrome patients
Thursday 16 October, 2025
Objectives: NNZ-2566 is a synthetic analog of a naturally occurring neurotrophic peptide derived from insulin-like growth factor-1 (IGF-1). It has…
Read morePopulation pharmacokinetic analysis of oxcarbazepine in patients with epilepsy
Thursday 16 October, 2025
Objectives: Oxcarbazpine is a widely used anticonvulsant drug to treat partial seizure as monotherapy or adjunctive therapy. The mono-hydroxylated derivative…
Read moreEffect of Valproic Acid Daily Dose on Phenobarbital Clearance – Nonlinear Mixed Effects Modelling Approach
Thursday 16 October, 2025
Objectives: The aim of the study was to explore impact of valproic acid (VPA) daily dose on phenobarbital (PB) oral…
Read moreNonlinear mixed effects modelling approach in investigating amitriptyline pharmacokinetics
Thursday 16 October, 2025
Objectives: The aim of the study was to investigate pharmacokinetic characteristics of amitriptyline (AMT) and influence of different variability factors…
Read morePopulation pharmacokinetic model of topiramate and its major metabolite in adult epileptic patients
Thursday 16 October, 2025
Objectives: The aim of the study was to characterize metabolic profile of topiramate (TPM) and to assess influence of enzyme…
Read moreA repeated time-to-event model for epileptic seizures in patients undergoing antiepileptic drug withdrawal during Video-EEG monitoring
Thursday 16 October, 2025
Objectives: Video-electroencephalography (VEEG) monitoring is the gold standard for diagnosis of patients with seizure-related disorders. The aims of this study…
Read moreIdentifying neuropsychological domains with high information on early signs of cognitive decline: An application of Item Response Theory in the Basel Study on the Elderly
Thursday 16 October, 2025
Objectives: The goal was to investigate which cognitive domains carry most information in the earliest stages of cognitive decline. This…
Read morePopulation pharmacokinetic modeling and simulation of moxifloxacin in human aqueous humor after topical ocular application
Thursday 16 October, 2025
Background: The fourth-generation fluoroquinolone moxifloxacin is currently one of the antibiotic agents of choice for cataract surgery in most countries….
Read more