Thursday 16 October, 2025
Objectives: To develop PK/PD models to characterize the exposure and heart rate (HR) relationship in a thorough QT (TQT) study for…
Read morePoster: Drug/Disease modeling - CNS
Model-based assessment of risks and benefits of tissue plasminogen activator treatment in acute ischemic stroke
Thursday 16 October, 2025
Objectives: Although thrombolysis with recombinant tissue plasminogen activator (t-PA) is licensed for treatment of stroke, it has been an important…
Read moreExposure-response analysis of Axomadol in patients suffering from hip and/or knee-joint osteoarthritis pain
Thursday 16 October, 2025
Objectives: Axomadol is a central analgesic, antinociceptive agent that was developed for the management of acute and chronic pain of…
Read moreA population pharmacokinetic analysis of levetiracetam in patients with epilepsy
Thursday 16 October, 2025
Objectives: Levetiracetam is commonly used as mono- or adjunctive therapy for the treatment of patient with partial and generalized epilepsy….
Read morePopulation Pharmacokinetic Model of Valproic Acid in Adult Patients: an Update
Thursday 16 October, 2025
Objectives: The main goal of this work was to develop an updated population pharmacokinetic model to identify and quantify the influence…
Read morePopulation Pharmacokinetics of Phenobarbital in Children, Adolescents and Young Adults Patients.
Thursday 16 October, 2025
Objectives: The main goal of this work was to develop an updated population pharmacokinetic model to identify and quantify the influence…
Read moreThe Effect of Anthropometric Covariates on Clearance of Valproic Acid.
Thursday 16 October, 2025
Objectives: The main goal of this study was to evaluate the effect of anthropometric covariates on the clearance (CL) of valproic…
Read morePBPK modeling of CNS distribution for risperidone and its active metabolite, paliperidone
Thursday 16 October, 2025
Objectives: Prediction of exposure level in the central nervous system (CNS) is critical during the development of CNS-targeted and non-targeted…
Read moreModelling drug-drug interactions between morphine and methylnaltrexone
Thursday 16 October, 2025
Objectives: To establish the population PKPD relationship of morphine after rectal administration using pupillometry as a central biomarker. Furthermore, to evaluate…
Read morePharmacokinetic Metamodel of Morphine and Morphine-6-Glucuronide in Neonates and Adults
Thursday 16 October, 2025
Objectives: Morphine is the gold standard opioid to treat moderate to severe pain. Morphine-6-glucuronide (M6G) is an active metabolite and contributes…
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