Thursday 16 October, 2025
Objectives: In order to understand the nonlinear pharmacokinetic behavior of phenytoin (PHT), a population pharmacokinetic model of PHT and its main…
Read morePoster: Drug/Disease modeling - CNS
Population Pharmacokinetics (PK) and Pharmacodynamics (PD) of Natalizumab in Patients with Multiple Sclerosis (MS)
Thursday 16 October, 2025
Objectives: Natalizumab is a first-in-class, humanized anti-α4 integrin antibody used to treat MS. Currently, no robust quantitative models describe the PK…
Read moreA population disease progression model for Amyotrophic Lateral Sclerosis – Results of the Treeway Summer Challenge 2015
Thursday 16 October, 2025
Background: Amyotrophic lateral sclerosis (ALS) is a progressive and deadly motor neurone disease, in which the motor neurons innervating skeletal…
Read moreEffect of psychotic subtypes on cognitive trajectories in Alzheimer’s disease Neuroimaging Initiative ADNI2.
Thursday 16 October, 2025
Objectives: The psychosis phenotype in Alzheimer’s disease (AD) may be comprised of two subtypes: paranoid (persecutory delusions), and misidentification (misidentification…
Read morePopulation exposure –response analysis of “On-Off” time in Individuals with Parkinson Disease following Preladenant Treatment
Thursday 16 October, 2025
Objectives: Preladenant is an Adenosine type 2A (A2a) receptor antagonist that was in development for Parkinson Disease (PD). Population exposure-response analysis…
Read moreResponse surface analysis of synergistic interactions of morphine and gabapentin in a rat model of postoperative pain.
Thursday 16 October, 2025
Objectives Despite much evidence that combination of morphine and gabapentin can be beneficial for managing postoperative pain, the nature of…
Read morePopulation modelling of the synergistic effects of morphine and gabapentin in the rat: a response surface approach
Thursday 16 October, 2025
Objectives: Combination of morphine and gabapentin has shown to be promising for managing postoperative pain [1]. Finding the right combination however…
Read moreUsing Item response theory to yield information from the MDS-UPDRS items in Parkinson’s disease clinical trials
Thursday 16 October, 2025
Objectives: Item response theory (IRT) has been recently introduced in pharmacometrics by Ueckert et al. to model the Alzheimer’s disease progression…
Read moreModelling Amyloid- ß levels in the presence of a gamma-secretase inhibitor
Thursday 16 October, 2025
Objectives: To develop a mathematical model to describe Amyloid- β (Aβ) dynamics and to identify and analyze the factors in the…
Read morePopulation pharmacokinetics of morphine and its metabolites M3G and M6G in morbidly obese patients and healthy volunteers
Thursday 16 October, 2025
Objectives: Morbidly obese patients are at increased risk of side effects of opioids, especially after surgery[1]. While in clinical practice…
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