Thursday 16 October, 2025
Introduction: Therapeutic drug monitoring is widely practiced for busulfan (Bu), with the aim of ensuring exposure into the therapeutic zone [1]….
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Successful validation of a model-informed precision dosing instrument for meropenem in critically ill patients, the DoseCalculator, against NONMEM®
Thursday 16 October, 2025
Objectives: Model-informed precision dosing (MIPD) instruments can optimise antibiotic therapy by translating available clinical data to individualised dosing recommendations but…
Read moreCapped dosing of desmopressin in Von Willebrand disease: Quantification of the relationship between desmopressin plasma concentration and Von Willebrand factor activity
Thursday 16 October, 2025
Introduction: Von Willebrand disease (VWD) is the most common inherited bleeding disorder and is caused by a deficiency or qualitative…
Read moreWhat clindamycin dose for which administration route in case of combination with rifampicin?
Thursday 16 October, 2025
Background: Clindamycin is an antibiotic frequently used in the treatment of bone and joint infections (BJIs) and is often co-administered…
Read moreA step towards automated and individualized first dose of vancomycin
Thursday 16 October, 2025
Objectives: Vancomycin is a commonly used antibiotic at Intensive Care Units for gram-positive infections.1 With the current dosing regimen, the…
Read morePopulation pharmacokinetic modelling of levetiracetm in criticaclly ill patients. Influence of creatinine clearance on the probability to attain target concentrations.
Thursday 16 October, 2025
Objectives: Levetiracetam is a broad-spectrum antiepileptic drug commonly used in seizure treatment and prophylaxis in the intensive care units (ICUs). Augmented…
Read morePopulation pharmacokinetic modelling and Monte Carlo simulation of piperacillin administered as extended infusion in critically ill patients
Thursday 16 October, 2025
Introduction/Objectives: Piperacillin/tazobactam is a beta-lactam/beta-lactamase inhibitor combination with activity against gram-positive and gram-negative aerobic and anaerobic bacteria [1]. Piperacillin exhibits…
Read moreDevelopment of covariate-informed model pooling method to predict the correct starting dose
Thursday 16 October, 2025
Objectives: An increasing number of population pharmacokinetic (POP-PK) models have been developed which can predict plasma concentrations based solely on…
Read moreA physiologically based computational model of indocyanine green liver function tests predicts survival in hepatectomy
Thursday 16 October, 2025
Objectives: The evaluation of hepatic function and functional capacity of the liver are essential tasks in hepatology, especially in the…
Read morePopulation pharmacokinetics of cefazolin in maternal and umbilical cord plasma, and exposure in term neonates
Thursday 16 October, 2025
Introduction: Intrapartum administration of cefazolin, a first-generation cephalosporin, is used to prevent vertical transmission of Group B Streptococcus (GBS) in…
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