Thursday 16 October, 2025
Introduction: Posaconazole is a broad-spectrum triazole antifungal drug used for prophylaxis and treatment of invasive fungal infections in critically ill…
Read morePoster: Clinical Applications
Population pharmacokinetics of vadadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor for treatment of anemia associated with chronic kidney disease
Thursday 16 October, 2025
Objectives: Vadadustat (VADA) is a synthetic, orally bioavailable, small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase enzymes under development for…
Read moreEvaluating the influence of genotype on warfarin dose predictions made using a theory-based PKPD model.
Thursday 16 October, 2025
Objectives: Warfarin continues to be the mainstay of oral anticoagulation therapy, however, a narrow therapeutic range poses a barrier to…
Read morePharmacogenetics-Based Population Pharmacokinetic Analysis for Dosing Optimization of Ritonavir-Boosted Atazanavir in Thai adult HIV-Infected Patients
Thursday 16 October, 2025
Objectives: In Thailand, Ritonavir-Boosted Atazanavir (ATV/RTV) is a preferred protease inhibitor based-regimen for the treatment of HIV infection. The pharmacokinetics…
Read moreSimulation based assessment of different dosing strategies for anti-TNFα monoclonal antibodies in Crohn’s disease patients
Thursday 16 October, 2025
Introduction: Anti-tumour necrosis factor α (TNFα) monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn’s Disease (CD). However,…
Read moreA multi-model averaging approach improves the performance of model-guided infliximab de-escalation in patients with inflammatory bowel diseases
Thursday 16 October, 2025
Objectives: Underexposure to infliximab is a common cause of loss of response in patients with inflammatory bowel diseases. Dosage regimen escalations…
Read moreEstablishing evidence for improved outcomes for HIV+ patients receiving antiretroviral drugs through home delivery
Thursday 16 October, 2025
Objectives: Establishing evidence for interventions that may improve patient care, using data routinely available in electronic healthcare records (EHR), is…
Read moreModel-Informed Precision Dosing of Tacrolimus in Lung Transplantation Early After Surgery Using Model-Predictive Control in the tdmore Framework
Thursday 16 October, 2025
Introduction: Tacrolimus is a critical immunosuppressant drug used in transplantation, but its narrow therapeutic index and highly variable bioavailability make…
Read moreDevelopment of an adaptive dosing approach for doxorubicin in paediatric cancer patients
Thursday 16 October, 2025
Objectives: Anthracyclines, such as doxorubicin, are known for causing potentially irreversible cardiotoxicity. Paediatric cancer patients are at the highest risk…
Read moreExploring practical limitations of model-based Bayesian dose optimization in intensive care patients
Thursday 16 October, 2025
Introduction Model-based dose adaptation (MBDA) based on empirical Bayes estimates (EBE) plays an important role in optimizing drug treatment in…
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