Thursday 16 October, 2025
Introduction: Hepatitis B is an infectious disease caused by hepatitis B virus (HBV) that affects the liver. 15% to 40%…
Read morePoster: Clinical Applications
Amikacin dose optimization in the emergency department: A population pharmaco-kinetic simulation study
Thursday 16 October, 2025
Objectives: Sepsis related to Gram-negative infections is a life-threatening organ dysfunction responsible for 11 million deaths per year worldwide [1]….
Read moreA Population Pharmacokinetic Model for Creatinine with and without ingestion of cooked meat
Thursday 16 October, 2025
Introduction: Estimated glomerular filtration rate (GFR) based on serum creatinine is now widely reported by clinical laboratories, and in most…
Read morePharmacometrics-based analysis of long-acting cabotegravir over 6 months in real-life people living with HIV in Switzerland
Thursday 16 October, 2025
Introduction: The present study is part of an ongoing nationwide multicenter observational study within the Swiss HIV Cohort Study for…
Read morePopulation pharmacokinetic modelling to characterize the effect of chronic kidney disease on tenofovir exposure after tenofovir alafenamide administration
Thursday 16 October, 2025
Objectives: Tenofovir alafenamide (TAF) is gradually replacing tenofovir disoproxil fumarate (TDF), both prodrugs of tenofovir (TFV), in HIV prevention and…
Read morePharmacokinetics of cefotaxime in intensive care patients: exploration of the sources of variability with a population model
Thursday 16 October, 2025
Objectives: Cefotaxime is a beta-lactam antibiotics commonly used in intensive care unit (ICU) patients. In this population, pathophysiological modifications induce a…
Read moreModel-informed Precision Dosing for vancomycin in children between 28 days and 18 years: Does the use of a multi-model approach improve the predictive performance?
Thursday 16 October, 2025
Objectives: Model-informed precision dosing (MIPD) using Bayesian forecasting is a useful tool for individualizing therapy in children and thus may…
Read moreInforming the selection of clinically relevant pharmacokinetic target range for Therapeutic Drug Monitoring (TDM) of sunitinib: a pharmacometric simulation framework
Thursday 16 October, 2025
Objectives: Sunitinib is commonly used to treat gastrointestinal stromal tumors (GIST) and metastatic renal cell carcinoma (mRCC). With sunitinib exposure…
Read morePharmacokinetically-guided dosing to improve the efficacy of brigatinib in non-small cell lung cancer patients
Thursday 16 October, 2025
Introduction: Brigatinib is a recently approved drug for the treatment of anaplastic lymphoma kinase-positive non-small cell lung cancer (ALK+ NSCLC)….
Read moreA meta-analysis for predicting early bactericidal activity of beta-lactam antibiotics against pulmonary tuberculosis
Thursday 16 October, 2025
Introduction: Tuberculosis is a leading cause of mortality among infections, with 6.4 million new diagnosis and 1.6 million deaths in…
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