Thursday 16 October, 2025
Pharmacokineticists are usually attempting to improve the ways in which they are developing models and have therefore been interested in…
Read moreoral presentation
Evaluating Pharmacokinetic/Pharmacodynamic Models Using The Posterior Predictive Check
Thursday 16 October, 2025
The properties of the posterior predictive check (PPC) for pharmacokinetic and pharmacodynamic model validation is examined. The PPC assigns a…
Read moreUse of a Therapeutic Model for Simulating Phase III Clinical Trials of a New Bradycardic Agent
Thursday 16 October, 2025
Introduction: Monte Carlo simulation is used for determining the dose and number of subjects needed for a phase III clinical…
Read moreBootstrap Methods
Thursday 16 October, 2025
Bootstrap methods are simulation approaches to inference for statistical problems where large-sample approximations are unreliable, where parametric assumptions cannot be…
Read moreDevelopment of a Linked Pharmacokinetic and Pharmacodynamic Simulation Model for Ivabradine in Healthy Volunteers
Thursday 16 October, 2025
Ivabradine is a novel bradycardiac agent that has been developed for the treatment of angina and tachyarrhythmias. Ivabradine has an…
Read morePopulation Pharmacokinetic Parameters of Doxorubicin, Ifosamide and Etoposide in Small Cell Lung Cancer Patients
Thursday 16 October, 2025
Purpose: (i) To determine the population pharmacokinetic (PK) parameters of Doxorubicin (Dox), Etoposide (Eto) and Ifosfamide (Ifo) in small cell…
Read moreRole of modelling and simulation in Phase I drug development
Thursday 16 October, 2025
Although the use of pharmacokinetic/pharmacodynamic modelling and simulation (M&S) in drug development has increased during the last decade, this has…
Read moreThings you may have wanted to ask about the $ESTIMATION record but have been hesitant to ask
Thursday 16 October, 2025
The $ESTIMATION record is a NONMEM control record, giving control information regarding the Estimation Step. It contains a number of…
Read moreChecking departure from normality of the random effect
Thursday 16 October, 2025
When a kinetic study is performed, concentrations and covariates are measured on different individuals. Then, using a population pharmacokinetic model,…
Read moreOptimal Design Of A Population Pharmacodynamic Experiment
Thursday 16 October, 2025
Background: Methods for optimal design of population pharmacokinetic experiments using the population Fisher information matrix (PF) have been developed recently….
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