Thursday 16 October, 2025
To approve a new drug for marketing, regulatory authorities generally require “substantial evidence” that it is effective relative to some…
Read moreoral presentation
Constructing optimal designs for fitting pharmacokinetic models
Thursday 16 October, 2025
A brief review will be given of the available approaches to constructing optimal designs and an assessment of their usefulness…
Read moreA Pharmacodynamic Markov Mixed Effect Model for Temazepams Effect on Sleep
Thursday 16 October, 2025
Background: In hypnograms, sleep is continuously monitored and sleep stage is routinely scored every 30 seconds. Direct analysis of such…
Read morePopulation PK/PD Of Craving Symptoms In An Enforced Smoking Cessation Population: Probabilistic And Indirect Modelling Approach.
Thursday 16 October, 2025
Objective: A placebo controlled, randomised, double blind, three periods, crossover trial was designed to investigate the relationship between craving scores…
Read moreValidation Methods In Population Pharmacokinetics: A New Approach Based On Predictive Distributions With An Evaluation By Simulation
Thursday 16 October, 2025
We developed a validation approach based on predictive distributions for nonlinear mixed- -effects models. This validation method is to be…
Read moreOptimal population designs for enoxaparin pharmacokinetics: evaluation by simulation
Thursday 16 October, 2025
We wished to optimise population pharmacokinetics designs under different constraints and to evaluate them by simulation for a new phase…
Read moreIn Search of an Optimal Furosemide Infusion Strategy in Children after Cardiac Surgery Using Modelling and Simulation
Thursday 16 October, 2025
Background Furosemide is frequently used in children to increase urinary output after cardiopulmonary bypass, but the optimal dosing strategy is…
Read morePopulation Pharmacokinetics in Paediatric Patients; the Good, the Bad and the Ugly
Thursday 16 October, 2025
Drug administration to paediatric patients presents a number of challenges due to their immature renal and hepatic function and differences…
Read morePharmacokinetic/Pharmacodynamic Modeling of the Antipyretic Effect of Two Oral Formulations of Ibuprofen: Suspension and Effervescent Granules
Thursday 16 October, 2025
The population pharmacokinetic-pharmacodynamic relationships of racemic ibuprofen administered in suspension or effervescent granules were analyzed. Pharmacokinetics was studied in eighteen…
Read moreThe impact of patient compliance in pharmacokinetic/pharmacodynamic studies
Thursday 16 October, 2025
Population pharmacokinetics (PK) and pharmacodynamics (PD) study the variability between individuals in drug concentration and pharmacological effect when standard dosage…
Read more