Thursday 16 October, 2025
COST B15 held a meeting in Brussels on the 7-8th March 2001 to discuss the role of modelling and simulation…
Read moreoral presentation
On mechanism based PK/PD modelling for direct drug-ligand binding systems
Thursday 16 October, 2025
The most common method to model drug effects normally involves either an empirical dose-response system, or a PK/PD system where…
Read morePhysiologically based pharmacokinetic modeling in risk assessment -Development of Bayesian population methods
Thursday 16 October, 2025
In the field of risk assessment, extrapolation of kinetic results, between species or from in vitro to in vivo conditions,…
Read moreDetermination of Inclusion Frequency of False Covariate Relationships in Population Modelling
Thursday 16 October, 2025
Whenever exploratory methods for detection of covariate relationships are used in population PK/PD modelling, there is a risk of including…
Read moreA Population Pharmacokinetic and Pharmacodynamic Analysis of Sildenafil Phase III Data
Thursday 16 October, 2025
Sildenafil is an orally administered compound developed and approved for the treatment of erectile dysfunction (ED). A population pharmacokinetic sampling…
Read moreThe Use of Priors in NONMEM Population Analysis
Thursday 16 October, 2025
Modelling of drug behavior during drug development is usually an on-going process, where the models are refined, validated and expanded…
Read moreRobust optimal design for hyperparameter estimation
Thursday 16 October, 2025
The design of a population pharmacokinetics study can be optimized to improve the accuracy and the precision of hyperparameter (y)…
Read moreCombining PK and PD data during population PK/PD analysis
Thursday 16 October, 2025
There are two general alternatives for combining pharmacokinetic (PK) and pharmacodynamic (PD) data during a population analysis. First, the data…
Read morePopulation Analysis (NONMEM) using a Concentration-to-Event Approach to Evaluate the Propofol Anaesthesia Induction Strategy using a Target Controlled Infusion (TCI) System: Diprifusor TCI
Thursday 16 October, 2025
Introduction: The ‘Diprifusor’ target controlled infusion (TCI) device is currently used as a standardised computer-assisted infusion system for the administration…
Read morePopulation PK/PD Modeling and Optimal Drug Dosage
Thursday 16 October, 2025
Population PK/PD modeling describes variability between and within subjects. It employs the stated assay variability. Parametric (P) population modeling obtains…
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