Thursday 16 October, 2025
1Ondansetron is a 5-HT3 receptor antagonist used for the prevention and/or treatment of cancer chemotherapy- and radiotherapy-induced emesis and post-operative…
Read moreoral presentation
Analyzing Odd Type Data Using NONMEM
Thursday 16 October, 2025
Population methodology is all about distinguishing between inter-subject and intra-subject random variabilty. Initially, population methodology was applied to the analysis…
Read moreA Preview of NONMEM Version V
Thursday 16 October, 2025
NONMEM version IV was released in 1992. Work on version V actually com- menced before that time. Version V incorporates…
Read moreA Population Markov Model For Analyzing Dose History
Thursday 16 October, 2025
Drug taking behavior (compliance) varies between and within patients, as revealed by electronic monitoring devices placed on pill containers. In…
Read moreIndividualized Drug Therapy And Population Modeling
Thursday 16 October, 2025
What is the clinical relevance of population modeling approaches ? We need the results of population studies as Bayesian priors…
Read moreA Population PK/PD Model For The Anti-Parkinsonian Triple Therapy: Levodopa (Ld), Dopadecarboxylase (Ddc) Inhibitor And Catechol-O-Methyl Transferase (Comt) Inhibitor
Thursday 16 October, 2025
Patients developing ParkinsonÃs disease respond well to treatment with LD, but its short half-life necessitates frequent dosing and often leads…
Read moreXPose – An S-Plus Based Model Building Aid For Population Analysis With Nonmem
Thursday 16 October, 2025
One of the keys to rapid and successful data analysis is the use of informative graphics, both as a way…
Read moreOptimal Design In Population Pharmacokinetics
Thursday 16 October, 2025
The accuracy of the estimator of pharmacokinetic parameters using standard nonlinear regression is related to the experimental design. Many developments…
Read moreLeflunomide Populationpharmacokinetics And Its Interaction With Activated Charcoal/Cholestyramine
Thursday 16 October, 2025
Leflunomide is an isoxazole immunosuppresive agent with clinically proven efficacy in rheumatoid arthritis. Following oral administration, the highly non-polar prodrug…
Read moreSimulating PK/PD Trials
Thursday 16 October, 2025
How to design a PK/PD trial? An answer for a specific situation involves many considerations of many different types. Following…
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