Thursday 16 October, 2025
There is increasing interest in methodologies that can simulate clinical trial results. We present a paradigm for validating such methodologies,…
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New Developments In The BUGS Software For Bayesian Modelling
Thursday 16 October, 2025
BUGS is a program that carries out Bayesian inference on complex statistical models for which there may be no exact…
Read moreNPML-Fit: A Graphical Nonparametric Population Modelling Program
Thursday 16 October, 2025
(The Non-parametric Maximum Likelihood method (NPML) has been proposed for estimating the joint distribution of the parameters of a given…
Read moreXPose 2.0 – An S-Plus Based Population Model Building Aid For NONMEM
Thursday 16 October, 2025
In population analysis we usually deal with data having a complex structure and with models that involves a large number…
Read moreNeural Network Prediction Of Dose And PP Parameters Values From A Population Approach Point Of View: Some Examples And Comments
Thursday 16 October, 2025
An approach using neural networks (N.N.) was used to predict PK and PD observations in several population studies. Neural networks…
Read moreComparison Of ED, EID, API And Bayesian-API Criteria For The Robust Optimisation Of Sampling Times In Pharmacokinetics.
Thursday 16 October, 2025
The most usual approach for optimization of sampling schedule in pharmacokinetics is the D-optimality criterion which consists in maximizing the…
Read moreA Population PK/PD model for the irreversible inhibition of 5alpha-reductase types 1 and 2, and the effects on plasma dihydrotestosterone levels.
Thursday 16 October, 2025
Dihydrotestosterone (DHT) is thought to be the androgen primarily responsible for the development of benign prostatic hyperplasia. Testosterone is converted…
Read moreThe Use Of Compliance Data In The Analysis Of A Clinical Trial Of Antiretroviral Drugs In HIV+ Individuals
Thursday 16 October, 2025
Non-compliance with study medications can influence the results of clinical trials. It has been hypothesised that a model-based analysis of…
Read moreNon-Stationarity Of Kinetic Parameters In Multi-Occasion Designs
Thursday 16 October, 2025
Several studies in pharmacokinetic literature reveal variations in time of individual kinetic parameters. An interesting one is that of Tornatore…
Read moreTwo-Stage Procedures For The Analysis Of Cross-Over Trials Using Pharmacokinetic And Pharmacodynamic Models
Thursday 16 October, 2025
The two-stage procedure for nonlinear mixed model fitting is extended to fit pharmacokinetic/pharmacodynamic (PK/PD) data in cross-over trials. Two approaches…
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