Thursday 16 October, 2025
In a population pharmacokinetic analysis we generally use parametric functions (e.g. exponentials) to describe drug disposition and input rate functions….
Read moreoral presentation
Under-Compliance And Population Pharmacokinetics
Thursday 16 October, 2025
One of the key considerations in designing experiments for population PK-PD determinations, is knowing as precisely as possible the inputs,…
Read moreAssumption Testing In Population Pharmacokinetic Models
Thursday 16 October, 2025
Deriving a population pharmacokinetic model from real data is always associated with numerous assumptions. Violations of these assumptions, especially if…
Read moreDetermination of the Population Pharmacokinetics of Bismuth from GR122311X in Healthy Volunteers using the Gibbs Sampler Bayesian Method.
Thursday 16 October, 2025
GR122311X (ranitidine bismuth citrate) is a new chemical entity being developed for the treatment of peptic ulcer disease. Absorption of…
Read morePopulation Analysis of Ordinal Categorical Data.
Thursday 16 October, 2025
In some clinical trials the pharmacodynamic response is measured on an ordinal categorical scale. This means that each measured response…
Read moreThe Bayesian Approach To Categorical Responses
Thursday 16 October, 2025
There are many situations in pharmacodynamic modelling when a categorical response variable is obtained. Examples include pain scores, number of…
Read moreSubsequent Developments Of Formulas Designed For Predicting Carboplatin Clearance In Adults And In Children
Thursday 16 October, 2025
Ultrafiltrable carboplatin AUC has a major impact on its haematologic toxicity and seems to correlate with the therapeutic outcome. We…
Read morePopulation Pharmacokinetics Of Etoposide In Children.
Thursday 16 October, 2025
Etoposide has activity against a wide range of tumours, and in the UK over 70% of children with malignant disease…
Read moreMixed-Effects Modelling Of The Dose-AUC Relationship Of Saquinavir Single Dose In Healthy Subjects
Thursday 16 October, 2025
In studies in healthy volunteers, the protease inhibitor saquinavir (SQV) showed overproportional increase of AUC with dose, and dependency of…
Read moreThe pharmacokinetics of saquinavir: a Markov chain, Monte Carlo population analysis
Thursday 16 October, 2025
Saquinavir is an HIV proteinase inhibitor currently being developed as a treatment for HIV infection. The drug has potent (Ki…
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