Thursday 16 October, 2025
S-16257 belongs to the new pharmaceutical class of specific bradycardic agents. Its bradycardic activity is due to a direct effect…
Read moreoral presentation
Prediction of Simvastatin Pharmacological Response: A Population Analysis
Thursday 16 October, 2025
Simvastatin is a HMG CoA reductase inhibitor which reduces total cholesterol (TC) through its principal effect on LDL cholesterol (LDLC)….
Read morePopulation Pharmacokinetics of Tacrolimus in Liver Transplant Patients
Thursday 16 October, 2025
The population pharmacokinetics of the immunosuppressant drug tacrolimus were investigated in 172 patients, aged 18–66 years, following liver transplantation. Tacrolimus…
Read moreA Prospective Evaluation of Sparse Sampling for Toxicokinetics in the Course of Drug Development.
Thursday 16 October, 2025
Rationale. The main objectives of Toxicokinetics are to assess the animal exposure after drug administration across dose levels and genders,…
Read moreFrom Animal to Man
Thursday 16 October, 2025
There is no doubt that the knowledge of the animal kinetics, dynamics and metabolism of a drug contributes to optimal…
Read morePharmacokinetic/-Dynamic Modeling of a Bivariate Control System: Luteinizing Hormone and Testosterone Response to GnRH Antagonist Antide
Thursday 16 October, 2025
A pharmacodynamic analysis of the input-response relationship between the GnRH antagonist antide and luteinizing hormone and testosterone concentrations is presented….
Read morePopulation Approach to Nonlinear Pharmacokinetics of a New Drug under Development
Thursday 16 October, 2025
Problem If a drug is exclusively eliminated by a saturable process, a steady state concentration will only be established, when…
Read moreExperiences With Genotype And Phenotype Information In Mixed Effects Modelling
Thursday 16 October, 2025
One of the principal aims of performing mixed effects modelling has been to provide a means of identifying and quantifying…
Read moreCovariate Model Building In Population Analysis
Thursday 16 October, 2025
Being able to explain the variability of the parameters in a population model using covariates can have important consequences. One…
Read moreThe Estimation Of Drug-Drug Interactions In Population Pharmacokinetic Trials
Thursday 16 October, 2025
The purpose of searching for drug-drug interactions (DDIs) is to characterize subgroups of populations which require different dosing regimens compared…
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