Thursday 16 October, 2025
The influence of the choice of pharmacokinetic model on subsequent determination of covariate relationships in population pharmacokinetic analysis was studied…
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Diagnostics For Nonlinear Mixed Effects Models
Thursday 16 October, 2025
During the past few years nonlinear mixed effects modeling techniques have become more and more popular to estimate the distribution…
Read moreComparison of Bayesian Optimal Designs with Respect to Variations of the Population Characteristics. For a Pharmacokinetic and a Pharmacodynamic Model
Thursday 16 October, 2025
Once a parameter distribution of a pharmacokinetic or a pharmacodynamic model has been estimated in a given population a Bayesian…
Read moreThe Use of NONMEM in Interspecies Allometric Scaling
Thursday 16 October, 2025
Interspecies scaling of the pharmacokinetic parameters (P) is usually done using allometric equations as P= aWb, relating P to body…
Read moreA limited sampling model with Bayesian estimation to determine carboplatin pharmacokinetics in paediatrics
Thursday 16 October, 2025
Although carboplatin has a lower incidence of non-haematological toxicity than cisplatin, it is still important to ensure that patients receive…
Read moreCarboplatin Population Pharmacokinetics
Thursday 16 October, 2025
Carboplatin, a nonnephrotoxic but myelosuppressive antineoplastic analog of cisplatin, is an alternative for patients who cannot tolerate cisplatin toxicity. For…
Read moreIssues and Suggested Solutions in Drug Development
Thursday 16 October, 2025
The general industry view of population analysis tends to be NONMEM and something which provides the means of extracting information…
Read moreA Validation For A Population Pharmacokinetic Model For Docetaxel
Thursday 16 October, 2025
A limited sampling strategy has been designed and implemented in Phase II studies of docetaxel to perform a prospective population…
Read morePopulation Approaches in Drug Development: Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software
Thursday 16 October, 2025
Keywordspopulation approach, drug development, software, pharmacokinetics, pharmacodynamics Summary An expert meeting to discuss population pharmacokinetic/pharmacodynamic software was held in Brussels…
Read moreMixed-effects modeling and simulation of the Dose-AUC relationship of saquinavir in healthy subjects and HIV-positive patients (II)
Thursday 16 October, 2025
This abstract (ll) is the follow-up report of the abstract (1) presented at PAGE 1997 “Mixed-effects modeling of the Dose-AUC…
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