Thursday 16 October, 2025
Objectives: The aim of this study was to develop a disease progression model jointly for three stroke scales; the NIH…
Read moreOral Presentation: Applications
A Modeling and Simulation Case Study: Impact on an Early Clinical Development Program
Thursday 16 October, 2025
PDF of presentation A case study will be presented that illustrates the use of population modeling and clinical trial simulations…
Read moreCircadian rhythm in pharmacodynamics and its influence on the identification of treatment effects
Thursday 16 October, 2025
Objectives: Compound X is a aquaretic compound, being developed for the treatment of a specific kidney disease. Population PK-PD models…
Read moreApplication of modelling and simulation in clinical oncology
Thursday 16 October, 2025
Most of the cytotoxic agents currently used in cancer chemotherapy have been discovered decades ago. Dosing of these agents is…
Read moreModel-Based Drug Development: Optimization of AQUAVAN® Injection Dosing for Minimal-to-Moderate Sedation
Thursday 16 October, 2025
Background: AQUAVAN® (fospropofol disodium) Injection is a water-soluble prodrug of propofol being developed to induce minimal-to-moderate sedation for brief diagnostic…
Read moreModeling and Simulation of the Asenapine Exposure-Response and Drop-Out in Acute Schizophrenia
Thursday 16 October, 2025
Objectives: To characterize the efficacy time-course and drop-out in schizophrenic patients following placebo or asenapine treatment, to substantiate, by simulations,…
Read moreEnhancing Methotrexate Pharmacotherapy in Children with Cancer: A Decision Support System Integrating Real-time PK/PD Modeling and Simulation with Patient Medical Records
Thursday 16 October, 2025
Objectives: The use of pharmacokinetic (PK) and pharmacodynamic (PD) measurements in the clinical care of patients is often limited to…
Read moreBasic PK/PD principles of proliferative and circular systems
Thursday 16 October, 2025
Mathematical modelling is increasingly being applied to interpret and predict the dynamics of diseases (1,2,3). Within the infectious disease field…
Read moreImpact of handling missing PK data on PD estimation – explicit modeling of BLQ data in WinBUGS® reduced bias in the PD predictions – a preclinical example.
Thursday 16 October, 2025
Objectives: Purpose of this project was to compare 2 drugs, a lead compound and its backup on a pharmacodynamic endpoint…
Read moreA system model for the clotting cascade challenges clinical management of snake bites.
Thursday 16 October, 2025
Introduction: A procoagulant toxin is found in taipan snake venom. This toxin activates the coagulation cascade and causes venom-induced consumptive…
Read more