Only 5% of new molecules make it to the market in oncology, lowest compared to other therapeutic areas. Yet, cancer…
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Effect of Cranberry Juice on Population Pharmacokinetics of Amoxicillin and Cefaclor
Objectives: Consumption of cranberry juice with low-dose oral antibiotics is often prescribed as long-term therapy/prophylaxis for recurrent urinary tract infection….
Read moreIndividualized compared with conventional dosing of enoxaparin.
Introduction: There is widespread belief that individualizing dosing regimens of drugs will further optimize outcomes for each patient. However there…
Read moreModels of Glucose Metabolism and Control in Diabetes
Diabetes is one of the major chronic diseases, i.e. together with its complications it accounts for more than 10% of…
Read moreKinetic models of PSA decrease after surgery in prostate tumor diseases as a help for clinician interpretation
Objectives: In order to characterize Prostate Specific Antigen (PSA) compartments releases (anatomy transitional and peripheral zones) and prognostic value of…
Read moreModel-based dose adaptation of capecitabine for prevention of severe hand-and-foot syndrome: in silico comparison with the standard method
Introduction: Management of anticancer therapies is complex due to their narrow therapeutic indices (interval between minimum effective and toxic doses) and…
Read moreDeconvolution of Insulin Secretion Rates
Abstract is based on Master Project [4] and article [3] by Soren Klim and Stig Mortensen Objectives: Insulin and C-peptide…
Read morePlanning To Communicate
Objectives: As a discipline, Pharmacometics has matured to the point where no educated observer doubts that a skilled pharmacometrician can…
Read moreSimulation of the Nonlinear PK of Gabapentin and Midazolam in Adult and Pediatric Populations
PDF of presentationObjective: Demonstrate building GastroPlus(tm) models for the nonlinear dose dependencies for gut transporter and gut enzyme substrates in…
Read moreCystatin C as a new covariate to predict the renal elimination of drugs
Objectives. Individual dosing of drugs mainly eliminated by renal excretion is possible by estimation of the renal function. Most of…
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