Thursday 16 October, 2025
Objectives: An investigation into using adult data to predict paediatric tobramycin pharmacokinetics was undertaken. Tobramycin is a narrow therapeutic index…
Read moreOral Presentation: Applications
Developmental Pharmacokinetics of Diclofenac for Acute Pain
Thursday 16 October, 2025
Introduction: Diclofenac is an effective, opiate-sparing analgesic widely used for peri-operative pain in children [1] with single doses of 0.5-2mg/kg…
Read moreAcknowledging Parameter Uncertainty in the Simulation-Based Design of an Actinomycin-D Pharmacokinetic Study in Pediatric Patients with Wilms’ Tumor or Rhabdomyosarcoma
Thursday 16 October, 2025
Background: Actinomycin-D (AMD) has been used for the treatment of Rhabdomyosarcoma and Wilms’ tumor for over 40 years. Despite its…
Read moreOptimizing Dose Selection With Respect to Multiple Safety/Efficacy Endpoints Using Clinical Utility Concepts
Thursday 16 October, 2025
Objectives: An important aspect of dose selection for late phase studies is an evaluation of benefit/risk profiles of candidate dosing…
Read moreDetermining the effect of CYP2C9 genotypes on diclofenac metabolism using individualized coupled physiology-based pharmacokinetic modeling
Thursday 16 October, 2025
Objective: To determine the extent of diclofenac clearance due to hydroxylation to 4’-hydroxydiclofenac in 20 adults genotyped as CYP2C9 amino…
Read moreModeling Drug Effects and Resistance Development on Tumor Growth Dynamics
Thursday 16 October, 2025
Objective: The objective of this study is to develop a semi-mechanistic model to quantify tumor growth dynamics, the anticancer drug…
Read moreMechanism-based model of the effect of co-administration of exogenous testosterone and progestogens on the hypothalamic-pituitary-gonodal axis in men
Thursday 16 October, 2025
Objectives: Combined administration of testosterone (T) and progestogens has been investigated for the development of a male contraceptive method. Co-administration leads…
Read moreIntegrated Modeling & Simulation of Clinical Response and Drop-out of D2 receptor agonists in Patients with Early Parkinson’s Disease.
Thursday 16 October, 2025
Objectives: This Modeling & Simulation (M&S) project aimed to establish a simulation framework for efficacy of the D2 receptor agonist…
Read moreModeling of the induction of CYP2B6 and CYP2C19 by artemisinin antimalarials
Thursday 16 October, 2025
Introduction: Malaria is a global health problem with about 1-2 million deaths annually. Parasite resistance has been reported to existing…
Read moreIndividualization of Cefuroxime Dosage using Pharmacodynamic targets, MIC distributions and Minimization of a Risk Function
Thursday 16 October, 2025
PDF of presentation Objectives: When developing drug dosing strategies, benefits and disadvantages of treatment are balanced. For cephalosporins, such as…
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