Thursday 16 October, 2025
Introdu+E3:E26ction: Respiratory syncytial virus (RSV) is a major public health concern, particularly in infants and elderly (1). Despite its epidemiological…
Read moreOral: Drug/Disease Modelling - Other Topics
Predicting aberrant pharmacokinetics of bispecific antibody-derived molecules from in vitro gradient chromatographic assays and physiologically based pharmacokinetic (PBPK) modeling
Thursday 16 October, 2025
Objectives: Bispecific antibody-derived molecules (bsAbs) and half-life extended bsAbs (with YTE mutation) are an evolution of monoclonal antibodies (mAbs). Post-endocytosis,…
Read moreModelling the efficacy of antiviral strategies of SARS-CoV-2 in a context of emerging variants: from hospitalized patients to general community
Thursday 16 October, 2025
Objectives The severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a highly versatile virus that has shown a large capacity to…
Read moreA DeepNLME framework for modeling ordinal data to describe disease progression in patients with Alzheimer’s disease.
Thursday 16 October, 2025
Introduction: Disease modeling in pharmacometrics is essential for understanding and predicting disease progression and optimizing drug development, as it enables…
Read moreHow disability progression is correlated with serum neurofilament light chain dynamics in relapsing remitting multiple sclerosis patients treated with Alemtuzumab: results from a mechanistic drug disease joint model
Thursday 16 October, 2025
Introduction: Relapsing Remitting Multiple Sclerosis (RRMS) is an auto-immune disease characterized by demyelinating plaques in the central nervous system[1]. If…
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