Thursday 16 October, 2025
Introduction During the covid-19 pandemic, a large number of clinical prognostic scores have been proposed and evaluated for hospitalized patients,…
Read moreOral: Drug/Disease Modelling - Other Topics
Pharmacometric Modeling of Drug Adverse Effects: An Application of Mixture Models in Schizophrenia Spectrum Disorder Patients Treated with Clozapine
Thursday 16 October, 2025
Objectives: Clozapine is the drug of choice for treatment-resistant schizophrenia [1]. However, its use is limited to only 5% of…
Read moreAn age-dependent QSP model of Nf trafficking to optimize treatment in neurodegenerative diseases
Thursday 16 October, 2025
Introduction: Neurofilament (Nf) has been identified as a potential biomarker for different neurodegenerative diseases, including SMA and ALS [1,2], and…
Read moreSARS-CoV-2 mechanistic correlates of protection in non-human primates: insight from modelling response to vaccines.
Thursday 16 October, 2025
Objectives: Despite the development of efficient SARS-CoV-2 vaccines, the identification of correlates of protection (CoP) is essential for further vaccine development….
Read moreAn item response theory model with bounded integer subcomponents to describe the Mayo Clinic subscores in patients with ulcerative colitis
Thursday 16 October, 2025
Introduction: Clinical efficacy of drugs in development for the treatment of ulcerative colitis (UC) is measured through the Mayo Clinic…
Read moreA patient stratification tool for selecting tuberculosis treatment regimen composition and duration
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) treatment regimens endorsed by guidelines lack the flexibility needed to provide optimally safe and effective regimens for…
Read moreViral dynamics of the Respiratory Syncytial Virus during experimental challenge infections: insights for transmission and treatment
Thursday 16 October, 2025
Introdu+E3:E26ction: Respiratory syncytial virus (RSV) is a major public health concern, particularly in infants and elderly (1). Despite its epidemiological…
Read morePredicting aberrant pharmacokinetics of bispecific antibody-derived molecules from in vitro gradient chromatographic assays and physiologically based pharmacokinetic (PBPK) modeling
Thursday 16 October, 2025
Objectives: Bispecific antibody-derived molecules (bsAbs) and half-life extended bsAbs (with YTE mutation) are an evolution of monoclonal antibodies (mAbs). Post-endocytosis,…
Read moreModelling the efficacy of antiviral strategies of SARS-CoV-2 in a context of emerging variants: from hospitalized patients to general community
Thursday 16 October, 2025
Objectives The severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a highly versatile virus that has shown a large capacity to…
Read moreA DeepNLME framework for modeling ordinal data to describe disease progression in patients with Alzheimer’s disease.
Thursday 16 October, 2025
Introduction: Disease modeling in pharmacometrics is essential for understanding and predicting disease progression and optimizing drug development, as it enables…
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