Thursday 16 October, 2025
Objectives: Congenital adrenal hyperplasia (CAH) is characterised by a decreased or absent cortisol production, mainly caused by reduced 21-hydroxylase enzyme activity….
Read moreOral: Drug/Disease Modelling - Other Topics
Mathematical Modeling Of Gut Microbiota Diversity Under The Effects of Beta-lactam Antibiotics
Thursday 16 October, 2025
Introduction/Objectives Antibiotics treatments shift the composition of the gut microbiota according to their spectrum of activity, posology and intestinal excretion…
Read moreIntegrated modeling of digital-motor outcomes and clinical outcome assessments using IRT: a framework for developing better outcomes for clinical trials in rare neurological diseases
Thursday 16 October, 2025
Background: Effective trial planning for rare neurological diseases is often hindered by the lack of robust and sensitive endpoints. This…
Read moreItem Response Theory Analysis of the Scale for the Assessment and Rating of Ataxia in Autosomal Recessive Cerebellar Ataxias
Thursday 16 October, 2025
Background and objectives: Autosomal Recessive Cerebellar Ataxias (ARCAs) is a heterogenous group of rare and ultra-rare neurodegenerative genetic diseases that…
Read moreLongitudinal biomarkers predicting death of hospitalized patients for SARS-COV-2 infection: a joint analysis with competing risks
Thursday 16 October, 2025
Introduction During the covid-19 pandemic, a large number of clinical prognostic scores have been proposed and evaluated for hospitalized patients,…
Read morePharmacometric Modeling of Drug Adverse Effects: An Application of Mixture Models in Schizophrenia Spectrum Disorder Patients Treated with Clozapine
Thursday 16 October, 2025
Objectives: Clozapine is the drug of choice for treatment-resistant schizophrenia [1]. However, its use is limited to only 5% of…
Read moreAn age-dependent QSP model of Nf trafficking to optimize treatment in neurodegenerative diseases
Thursday 16 October, 2025
Introduction: Neurofilament (Nf) has been identified as a potential biomarker for different neurodegenerative diseases, including SMA and ALS [1,2], and…
Read moreSARS-CoV-2 mechanistic correlates of protection in non-human primates: insight from modelling response to vaccines.
Thursday 16 October, 2025
Objectives: Despite the development of efficient SARS-CoV-2 vaccines, the identification of correlates of protection (CoP) is essential for further vaccine development….
Read moreAn item response theory model with bounded integer subcomponents to describe the Mayo Clinic subscores in patients with ulcerative colitis
Thursday 16 October, 2025
Introduction: Clinical efficacy of drugs in development for the treatment of ulcerative colitis (UC) is measured through the Mayo Clinic…
Read moreA patient stratification tool for selecting tuberculosis treatment regimen composition and duration
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) treatment regimens endorsed by guidelines lack the flexibility needed to provide optimally safe and effective regimens for…
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