Thursday 7 May, 2026
Introduction: Based on 48 years of improving in-vitro fertilisation (IVF) treatment protocols, there is today a deep mechanistic understanding of…
Read moreOral: Drug/Disease Modelling - Other Topics
Modeling expanded disability status scale trajectories and their association with serum neurofilament light chan in alemtuzumab-treatment relapsing remitting multiple sclerosis patients
Thursday 7 May, 2026
Introduction: Relapsing‑Remitting Multiple Sclerosis (RRMS) is an autoimmune disease characterized by demyelinating lesions and progressive neurological impairment(1). While reducing relapse…
Read moreModelling jointly viral dynamic and fever during H1N1 infections in non-human primates
Thursday 7 May, 2026
Introduction: Pre-clinical modeling of viral dynamics has provided key insights during the covid-19 pandemic (specificities of each variant, treatment efficacy…
Read moreJoint modeling of time to positivity (TTP), mycobacterium tuberculosis – molecular bacterial load assay (TB-MBLA), and PATHFAST TB LAM AG test: Quantifying inter-biomarker correlations and drug effects in pulmonary tuberculosis
Thursday 7 May, 2026
Objectives: Tuberculosis (TB) remains a major global health crisis, with an estimated 10.7 million new cases and 1.23 million deaths…
Read moreA Quantitative System Pharmacology model for the development and optimization of mRNA vaccines.
Thursday 16 October, 2025
Introduction: The necessity of reducing time and costs in the development phase of a vaccine has been an open challenge…
Read moreVirtual population analysis of a Quantitative Systems Pharmacology (QSP) model of atopic dermatitis (AtD) to evaluate AtD treatments
Thursday 16 October, 2025
Introduction: Atopic dermatitis (AtD) is a chronic inflammatory skin condition characterized by eczematous lesions and intense itch [1]. The exact cause…
Read moreExpanding a quantitative systems pharmacology (QSP) modeling framework for acute Hepatitis B to characterize chronic infection
Thursday 16 October, 2025
Objectives: Chronic hepatitis B virus (HBV) infection is associated with high morbidity and mortality and represents an unmet medical need…
Read moreModeling the kinetics of the neutralizing antibody response against SARS-CoV-2 variants after several administrations of Bnt162b2 vaccine
Thursday 16 October, 2025
Objectives: Developed vaccines against SARS-CoV-2 have been a turning point against the ongoing Covid-19 pandemic by dramatically reducing the number…
Read morePBPK/PD modeling and machine learning approaches to support the development of new drugs and regimens against tuberculosis.
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) is a major global health problem that causes millions of new cases and deaths every year. Several…
Read moreSpatially and temporally resolved diffusion kinetics of bedaquiline and TBAJ-587 in hard-to-treat sites of TB disease
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) is an infectious disease that can lead to lung cavitation and death. In the hardest-to-treat population, those…
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