Thursday 16 October, 2025
Introduction: The necessity of reducing time and costs in the development phase of a vaccine has been an open challenge…
Read moreOral: Drug/Disease Modelling - Other Topics
Virtual population analysis of a Quantitative Systems Pharmacology (QSP) model of atopic dermatitis (AtD) to evaluate AtD treatments
Thursday 16 October, 2025
Introduction: Atopic dermatitis (AtD) is a chronic inflammatory skin condition characterized by eczematous lesions and intense itch [1]. The exact cause…
Read moreExpanding a quantitative systems pharmacology (QSP) modeling framework for acute Hepatitis B to characterize chronic infection
Thursday 16 October, 2025
Objectives: Chronic hepatitis B virus (HBV) infection is associated with high morbidity and mortality and represents an unmet medical need…
Read moreModeling the kinetics of the neutralizing antibody response against SARS-CoV-2 variants after several administrations of Bnt162b2 vaccine
Thursday 16 October, 2025
Objectives: Developed vaccines against SARS-CoV-2 have been a turning point against the ongoing Covid-19 pandemic by dramatically reducing the number…
Read morePBPK/PD modeling and machine learning approaches to support the development of new drugs and regimens against tuberculosis.
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) is a major global health problem that causes millions of new cases and deaths every year. Several…
Read moreSpatially and temporally resolved diffusion kinetics of bedaquiline and TBAJ-587 in hard-to-treat sites of TB disease
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) is an infectious disease that can lead to lung cavitation and death. In the hardest-to-treat population, those…
Read moreFrom physiology to disease: A quantitative framework for system-disease-drug interaction in cortisol replacement therapy
Thursday 16 October, 2025
Objectives: Congenital adrenal hyperplasia (CAH) is characterised by a decreased or absent cortisol production, mainly caused by reduced 21-hydroxylase enzyme activity….
Read moreMathematical Modeling Of Gut Microbiota Diversity Under The Effects of Beta-lactam Antibiotics
Thursday 16 October, 2025
Introduction/Objectives Antibiotics treatments shift the composition of the gut microbiota according to their spectrum of activity, posology and intestinal excretion…
Read moreIntegrated modeling of digital-motor outcomes and clinical outcome assessments using IRT: a framework for developing better outcomes for clinical trials in rare neurological diseases
Thursday 16 October, 2025
Background: Effective trial planning for rare neurological diseases is often hindered by the lack of robust and sensitive endpoints. This…
Read moreItem Response Theory Analysis of the Scale for the Assessment and Rating of Ataxia in Autosomal Recessive Cerebellar Ataxias
Thursday 16 October, 2025
Background and objectives: Autosomal Recessive Cerebellar Ataxias (ARCAs) is a heterogenous group of rare and ultra-rare neurodegenerative genetic diseases that…
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