34th PAGE Meeting

Dubrovnik - Croatia
2-5 June, 2026

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Abstracts (12)

I-081Simona Catozzi

A framework for drug safety assessment based on target affinity, drug exposure and plasma protein binding – dissecting FDA drug-induced cardiotoxicity data from a translational pharmacology perspective

Wed, Jun 3, 2026 10:00AM–12:00AM

I-082Seyeon Hwang

Comparative Acute Kidney Injury Risk Across Antibiotics Commonly Used for Severe Infections in Hospitalized Patients: A Time-Varying Causal Analysis

Wed, Jun 3, 2026 10:30AM–12:00PM

I-083Ke Szeto

MODEL-INFORMED COMPARATIVE PHARMACOKINETIC AND PHARMACOLOGIC PROFILING HIGHLIGHT JAK1 SELECTIVITY OF POVORCITINIB

Wed, Jun 3, 2026 10:30AM–12:00PM

II-081Geraldine Celliere

Handling Hysteresis in Concentration–QTc Analysis: A PK/PD Effect-Compartment Approach Illustrated with Vanoxerine

Wed, Jun 3, 2026 3:20PM–4:50PM

II-082Klaus Lindauer

Concentration-QTc (C-QTc) analysis using PK/PD modeling to evaluate time- and exposure-dependent drug-induced QT interval prolongation

Wed, Jun 3, 2026 3:20PM–4:50PM

II-083Johannes Tillil

Model-based assessment of the prothrombin time test during transition from rivaroxaban to warfarin

Wed, Jun 3, 2026 3:20PM–4:50PM

III-081A. Yin Edwards

CONCENTRATION-QTC ANALYSIS OF TOVORAFENIB IN PATIENTS WITH RAF-ALTERED, RELAPSED/REFRACTORY PEDIATRIC LOW-GRADE GLIOMA, ADVANCED SOLID TUMORS AND MELANOMA

Thu, Jun 4, 2026 9:50AM–11:20AM

III-082Joanna Parkinson

Opemalirsen antisense oligonucleotide targeting the APOL1 mRNA does not prolong the QTc interval.

Thu, Jun 4, 2026 9:50AM–11:20AM

III-083Diego Vera-Yunca

Safety Analysis of SAB-142, a Fully Human Anti-Thymocyte Globulin, Demonstrates Immunomodulatory Effects on Lymphocytes

Thu, Jun 4, 2026 9:50AM–11:20AM

IV-081Nadja Haas

Pharmacometric Evaluation of Patient-Reported Symptom Burden in Oral Anticancer Therapy With Axitinib and Cabozantinib Using Minimal Continuous-time Markov Models

Thu, Jun 4, 2026 1:40PM–3:10PM

IV-082Gabriella Ribeiro

PREDICTION OF DRUG-DRUG INTERACTIONS BETWEEN AYAHUASCA ALKALOIDS AND SSRIS USING PBPK MODELING WITH EXPLORATORY ANALYSIS OF CYP2D6 POLYMORPHISMS AND BREAST MILK EXPOSURE

Thu, Jun 4, 2026 1:40PM–3:10PM

IV-083Yujie Yang

Optimizing Cyclosporine A Therapy in Pregnancy: A Maternal-Fetal Physiologically-Based Pharmacokinetic Modeling Approach

Thu, Jun 4, 2026 13:40PM–15:10PM