34th PAGE Meeting

Dubrovnik - Croatia
2-5 June, 2026

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Abstracts (14)

I-009Monir Bertayli

Use of a Clinical utility index to assess the opioid sparring effect between morphine and pregabalin and as aid in dose optimization.

Wed, Jun 3, 2026 10:30AM–12:00PM

I-010Jacqueline Ernest

MODEL-BASED BRIDGING OF EPLONTERSEN POPULATION PHARMACOKINETICS AND PHARMACODYNAMICS IN CHINESE HEALTHY VOLUNTEERS AND CHINESE PATIENTS WITH HEREDITARY TRANSTHYRETIN-MEDIATED AMYLOIDOSIS WITH POLYNEUROPATHY SUPPORTS GLOBAL DOSING REGIMEN WITHOUT DOSE ADJUSTMENT

Wed, Jun 3, 2026 10:30AM–12:00PM

I-011Anne Kümmel

EXPOSURE-RESPONSE RELATIONSHIP OF ONCE-MONTHLY SUBCUTANEOUS OLANZAPINE (TV-44749) FOR THE CLINICAL GLOBAL IMPRESSION-SEVERITY SCALE IN PATIENTS WITH SCHIZOPHRENIA

Wed, Jun 3, 2026 10:30AM–12:00PM

I-012Haiping Xu

Population Pharmacokinetic-Pharmacodynamic Modelling of Ciprofol in Chinese Elderly Patients Undergoing Orthopedic Surgery

Wed, Jun 3, 2026 10:30AM–12:00PM

II-009Jose M Calderin

POPULATION PHARMACOKINETIC MODELLING OF BEDAQUILINE IN CENTRAL NERVOUS SYSTEM TISSUES IN A RABBIT MODEL OF TUBERCULOUS MENINGITIS

Wed, Jun 3, 2026 3:20PM–4:50PM

II-010Ruben Faelens

Predicting Total Immunoglobulin G When Switching From Efgartigimod To Nipocalimab

Wed, Jun 3, 2026 3:20PM–4:50PM

II-011Karsten Kuritz

EXPOSURE-RESPONSE MODELING OF PANSS IN PATIENTS WITH SCHIZOPHRENIA TREATED WITH SUBCUTANEOUS OLANZAPINE LAI (TV-44749) WITH A JOINT DROPOUT MODEL

Wed, Jun 3, 2026 3:20PM–4:50PM

III-009Martina Chiesa

TOWARD A QUANTITATIVE SYSTEMS PHARMACOLOGY FRAMEWORK OF CELL-LEVEL ALPHA-SYNUCLEIN DYNAMICS

Thu, Jun 4, 2026 9:50AM–11:20AM

III-010Alzahra Hamdan

An Item Response Theory-Based Comparison of Multiple Versions of SARA Rating Assessment of Degenerative Ataxia in a SCA3 Cohort

Thu, Jun 4, 2026 9:50AM–11:20AM

III-011Angelica Quartino

POPULATION PKPD AND EXPOSURE–RESPONSE ANALYSIS OF EPLONTERSEN SUPPORTS 45 MG SC Q4W WITHOUT DOSE ADJUSTMENT IN HEREDITARY TRANSTHYRETIN-MEDIATED POLYNEUROPATHY

Thu, Jun 4, 2026 9:50AM–11:20AM

IV-008Orwa Albitar

PopPK and PKPD Modeling of Oral NLRP3 Inhibitor Supporting Dose Simulation in Parkinson’s Disease

Thu, Jun 4, 2026 1:40PM–3:10PM

IV-009Alex De Nardi

A MINIMAL MECHANISTIC QSP-READY MODEL TO BRIDGE AGGREPHAGY AND MTOR SIGNALING IN ALS

Thu, Jun 4, 2026 1:40PM–3:10PM

IV-010Petra Jauslin

POPULATION PHARMACOKINETIC ANALYSIS OF ORAL, INTRAMUSCULAR IMMEDIATE RELEASE AND SUBCUTANEOUS LONG-ACTING INJECTABLE OLANZAPINE

Thu, Jun 4, 2026 1:40PM–3:10PM

IV-011Camille Vong

A quantitative systems pharmacology (QSP) model of neuroinflammation in Mild Cognitive Impairment and early Alzheimer’s Disease dementia

Thu, Jun 4, 2026 1:40PM–3:10PM